Role of Mouse Allergen in Childhood Asthma

描述（由申请人提供）：这个K23奖的目的是提出一个培训计划，以发展万达Phipatanakul，医学博士成为一个成功的独立临床研究者，重点是室内过敏原对儿童哮喘发展和发病率的作用。Phipatanakul博士是一名经过委员会认证的儿科医生和过敏症专家/免疫学家，在室内过敏原和过敏性呼吸道疾病方面具有丰富的研究经验。她的职业发展计划包括正式的教学培训，强调参与设计和进行纵向观察试验和临床干预试验的分析和实践技能。她的发展计划包括：1）正式的教育课程，将为她提供临床科学硕士学位和过敏原水平灰尘样本分析培训，2）在有利于职业发展的良好环境中支持导师和顾问的合作，以及3）她的正式培训和指导应用到她的研究提案中。她的长期目标是联合收割机结合她的背景与这种进一步的培训，成为一个成功的独立的临床研究者。她的研究提案计划进一步评估小鼠过敏原在儿童哮喘中的作用。她的初步研究表明，小鼠过敏原可能很重要，但尚未得到充分研究。她的提案A部分的目的是通过家庭过敏原研究（PI Diane Gold，初级导师）中来自特应性家庭的505名婴儿的既定出生队列了解纵向观察试验。她的目的是评估：1）小鼠的报告将预测室内灰尘样品中增加的小鼠过敏原水平，2）小鼠暴露的报告和实际小鼠过敏原水平将预测哮喘的发展，和3）特应性致敏。她的提案的B部分的目标侧重于从她的试点小鼠过敏原干预研究中学习，她的目标是：1）评估她的数据，以确定她的干预是否降低了过敏原水平，2）获得关于哮喘发病率和肺功能的初步信息，并评估她的研究在考虑到她的飞行员的结构和样本量的情况下的局限性，3）并设计一个计划，将她的试点研究扩展到一个更广泛的波士顿目标哮喘干预试验，纳入社区倡导者和资源。这将有助于她将从研究中获得的知识转化为直接的社区利益。

DESCRIPTION (provided by applicant): The purpose of this K23 Award is to propose a training plan to develop Wanda Phipatanakul, MD into a successful independent clinical investigator with a focus in the role of indoor allergens on childhood asthma development and morbidity. Dr. Phipatanakul is a board-certified pediatrician and allergist/immunologist with prior research experience in indoor allergens and allergic respiratory disease. Her career development plan includes formal didactic training emphasizing the analytical and practical skills involved in designing and conducting longitudinal observational trials and clinical intervention trials. Her development plan includes: 1) formal educational coursework that will provide her with a Masters in Science of Clinical Science and training in dust sample analyses for allergen levels, 2) collaboration of supportive mentors and advisors in an excellent environment conducive for career development, and 3) application of her formal training and mentorship into her research proposal. Her long-term goal is to combine her background with this further training to become a successful independent clinical investigator. Her research proposal plans to further evaluate the role of mouse allergen in childhood asthma. Her preliminary studies have shown that mouse allergens may be potentially important and have not been well-studied. The aims in Part A of her proposal are to learn about longitudinal observation trials through an established birth cohort of 505 infants from atopic families in the Home Allergens Study (PI Diane Gold, Primary Mentor). She aims to evaluate whether: 1) report of mouse will predict increased mouse allergen levels in house dust samples and 2) report of mouse exposure and actual mouse allergen levels will predict development of asthma and 3) atopic sensitization. The aims in Part B of her proposal focus on learning from her pilot Mouse Allergen Intervention Study where she aims to: 1) evaluate her data to determine if her intervention decreased allergen levels, 2) obtain preliminary information on asthma morbidity and lung function and evaluate the limitations of her study given the structure and sample size of her pilot, 3) and design a plan to extend her pilot study into a more broad scaled Boston-targeted asthma intervention trial incorporating community advocates and resources. This will help her translate knowledge gained from her research into direct community benefit.