Cooperative Breast Cancer Tissue Resource

描述（由申请人提供） 乳腺癌组织资源合作组织（CBCTR）由美国国家癌症研究所赞助，为分子标志物的研究提供存档的石蜡固定标本。俄勒冈州波特兰的Kaiser Permanente（KPNW）自1994年以来一直是该项目的积极成员，并寻求在下一个供资期继续发挥这一作用。 CBCTR已经收集了超过9000个乳腺癌组织样本，并将其与癌症登记和医疗记录中的人口统计学，临床和结果变量相关联。病理材料可以作为个体患者经历的初始手术的块的切片提供，或者作为结合来自数百个标本的组织核心的组织微阵列提供。研究人员可以申请这种材料，以使候选预后标志物的测试和/或验证。一个独立的研究评估小组评估这些申请的科学价值和技术可行性。CBCTR协调委员会由四个研究中心的主要研究者组成，负责审查这些申请是否适合资源。 考虑因素包括成功的可能性、对工作量的影响以及对资源的持续运营和可用性的影响。KPNW在满足社区研究人员的要求的过程中提供了2400多个标本，并分发了数百个组织样本。此外，KPNW的调查人员和工作人员还为制定和修改日常业务中使用的程序、撰写关于CBCTR的论文和介绍、在科学会议上展示以及在科学界进行宣传工作做出了贡献。随着CBCTR接近其更广泛使用其标本的目标，特别是TMAs，KPNW随时准备从我们的档案中补充更多以前未经检查的标本。

DESCRIPTION (provided by applicant) The Cooperative Breast Cancer Tissue Resource (CBCTR) is sponsored by the National Cancer Institute to provide archival, paraffin-fixed specimens for the study of molecular markers. Kaiser Permanente, Portland, Oregon (KPNW) has been an active member of this project since 1994 and seeks to continue in this role in the next funding period. The CBCTR has collected over 9000 specimens of breast cancer tissue and linked it to demographic, clinical and outcome variables from cancer registries and medical records. The pathological material can be supplied as sections of blocks from the initial surgery undergone by individual patients or as a Tissue Microarray that combines tissue cores from hundreds of specimens. Researchers may apply for this material to enable the testing and/or validation of candidate prognostic markers. An independent Research Evaluation Panel evaluates these requests for scientific merit and technical feasibility. The Coordinating Committee of the CBCTR, comprising the Principal Investigators of the four sites, reviews these requests for appropriateness for the Resource. Considerations include the likelihood of success, impact on workloads and effect on the continuing operation and usability of the Resource. KPNW has contributed over 2400 specimens and distributed hundreds of tissue samples in the process of filling requests from researchers in the community. In addition, KPNW investigators and staff have contributed to the development and modifications of the procedures used in daily operations, to papers and presentations about the CBCTR, to displays at scientific meetings and to publicity efforts in the scientific community. As the CBCTR approaches its goal of wider use of its specimens, particularly of the TMAs, KPNW stands ready to replenish the collection with more, previously unexamined specimens from our files.