Neural Control of Breathing and Cardiovascular Function

描述（由申请人提供）：本申请寻求支持培训呼吸和循环神经控制的科学领导者。该计划将支持博士研究生，将根据其本科表现和未来职业的相关研究兴趣进行选择。我们设计了一个综合的培训计划，以准备这些未来的科学家将他们的技能应用于与呼吸和心血管功能的神经、行为和化学控制有关的肺和心血管功能障碍的问题。在过去的30年里，生理学和生物物理学博士培训项目，特别强调呼吸和心血管控制，已经有30多名学员毕业，他们在美国各地从事研究和教学。C. Ovid Trouth和V. J. Massari为项目联合主任，B. R. Coleman博士为部门主席，我们致力于集中和加强呼吸、气道和循环的神经和激素控制的研究。我们将在现有研究项目的基础上，最大限度地发挥我们在神经科学、呼吸和心血管生理学方面的优势，并扩大与解剖学、生物化学、药理学、生物学和医学等部门的现有研究人员的合作。我们在霍华德大学和合作强化研究机构的项目教师由声誉卓著的科学家、经验丰富的培训师和美国国立卫生研究院支持的研究人员组成，他们在呼吸、气道和心血管系统的神经和激素控制等相关领域工作，所有这些领域都包括基本的生物和临床成分。学生可以选择将他们的研究项目集中在呼吸控制、气道功能或心血管系统上。在这些相互关联的领域中，经验丰富的导师和杰出的合作研究人员的可用性以及这些领域之间的强烈互动是该提案的主要组成部分。“呼吸和循环的神经和激素控制”系列研讨会将作为这两个领域的学员的核心，提供正式的课程和互动的“正在进行的研究”组成部分。研究生将有机会选择基础科学课程，并将在稿件和拨款准备、教学和交流方面接受培训。我们将与凯斯西储大学、约翰霍普金斯大学、梅奥医学院、密歇根大学、威斯康星大学和耶鲁大学的指定学院合作，提供充满活力、专注的指导，激励学员发展坚实的学术生涯。

DESCRIPTION (provided by applicant): This application seeks support to train scientific leaders in neural control of breathing and circulation. This program will support Ph.D. graduate students that will be selected based on undergraduate performance and their relevant research interest for their future careers. We have designed an integrated training program to prepare these future scientists to apply their skills to problems in pulmonary and cardiovascular functional disorders in relation to neuronal, behavioral and chemical control of breathing, and cardiovascular functions. Over the last 30 years the Ph.D. training program in Physiology and Biophysics, with particular emphasis on respiratory and cardiovascular control has graduated more than 30 trainees who are in research and teaching throughout the U.S. Under the leadership of Dr. M. A. Haxhiu as Program Director, Drs. C. Ovid Trouth and V. J. Massari as Program Co-Directors, and Dr. B. R. Coleman, Departmental Chairperson, we are committed to focus and intensify research on neural and hormonal control of breathing, airways, and circulation. This will be accomplished by, building on current research programs and maximizing our strengths in neuroscience, respiration and cardiovascular physiology, and expanding existing collaborations with established investigators in the Departments of Anatomy, Biochemistry, Pharmacology, Biology and Medicine. Our program faculties at Howard University and at the Collaborative Intensive Research Institutions are comprised of well established scientists, experienced trainers, and NIH-supported investigators who are working in interrelated areas of neural and hormonal control of breathing, airways and the cardiovascular system, all of which encompass both basic biologic and clinical components. Students may choose to focus their research project in control of breathing, airway functions, or the cardiovascular system. The availability of experienced mentorship and outstanding Collaborative Research Faculty in these interrelated fields and the strong interaction between these fields are the major components of this proposal. A "Neural and Hormonal Control of Breathing and Circulation" Seminar Series will serve as a nucleus for the trainees from both fields by providing a formal curriculum and an interactive "research in progress" component. Graduate students will have the opportunity to select courses in the basic sciences and will be trained in manuscript and grant preparation, in teaching and communication. In collaboration with designated Faculty at Case Western Reserve University, Johns Hopkins University, Mayo Medical School, University of Michigan, University of Wisconsin, and Yale University, we will offer vigorous, focused mentorship that will motivate our trainees to develop solid academic careers.