TRAINING PROGRAM IN QUANTITATIVE BIOLOGY AND PHYSIOLOGY

超出所提供的空间。 有必要培养研究人员谁可以识别和处理问题的生物学和生理学从定量，综合（跨生物长度尺度）和系统的角度来看。该提案旨在通过建立一个跨学科的博士前培训计划来满足这一需求，该计划涉及将被安置在生物医学工程（BME）中的系统和综合生物学领域。我们的定量生物学和生理学培训计划将培养生物医学科学家，他们了解分子生物学，细胞生物学和生理学，同时具有强大的技术背景，从定量的角度处理生物和生理问题。我们将强调定量和数学建模技术，是机械的，结构上的基础上，往往在整个生物规模无处不在。我们的毕业生将获得必要的技能，广度和经验，以分支在生物或生理系统或过程的各个层面（分子，细胞组织，器官，复杂的生物动力学）。我们的计划代表了一个特殊的机会，以团结在波士顿大学三个部门：生物医学工程，生物学和数学;四个跨学科研究中心;和在分子生物学，细胞生物学和生物化学（MCBB）的跨学科计划。 我们将建立一个培训课程，包括严格的课程和实验室轮换暴露：（a）定量分子生物学，细胞生物学和生理学，和（B）基于工程的生物学在四个主题领域：分子生物学和遗传工程，细胞和组织生物力学和电生理学，器官和感觉系统，复杂的生物动力学。我们将要求学员进行论文研究，是跨学科的，综合的，定量的，并与实验数据。最后，我们将建立一个独特的身份为定量系统生物医学科学家参与我们的计划，通过几个互动组件，包括在定量生物学和生理学，学生教师科学课程务虚会，每月晚餐和期刊俱乐部系列研讨会。总之，我们的目的是产生综合的，定量的，面向系统的生物医学科学家，他们将在学术机构的生命科学界担任领导职务（例如，大学和教学医院）和工业。性能现场=

EXCEED THE SPACE PROVIDED. There is a need to develop researchers who can identity and approach problems in biology and physiology trom a quantitative, integrative (across biological length scales), and systems perspective. This proposal aims to fill this need by establishing an interdisciplinary Pre-doctoral training program addressing the Systems and Integrative Biology area that will be housed in biomedicalengineering (BME). Our TrainingProgram in Quantitative Biology and Physiology will produce biomedical scientists who understand molecularbiology, cell biology andphysiology simultaneously with a strong technical background to approach biological and physiological problems from a quantitative perspective. We will emphasize quantitative and mathematical modeling techniques that are mechanistic, structurally based, and often ubiquitous across biological scale. Our graduates will acquire the requisite skills, breadth, and experience to branch at all levels (molecular, cell-tissue, organ, complex biodynamics) of a biological or physiological system or process. Our program represents a special opportunity to unite three departments at Boston University: Biomedical Engineering, Biology, and Mathematics; four interdisciplinary research centers; and an interdisciplinary program in MolecularBiology, Cell Biology, and Biochemistry (MCBB). We will establish a curriculum for the trainingprogram that includes rigorous course and lab rotational exposure to: (a) quantitative molecular biology, cell biology, and physiology, and (b) engineering-based biology in four thematic areas: Molecular Biological and Genetic Engineering, Cellular and Tissue Biomechanics and Electrophysiology, Organ and Sensory Systems, and Complex Biodynamics. We will require trainees to conduct thesis research that is interdisciplinary, integrative, quantitative,and linked to experimental data. Finally, we will establish a unique identity for the Quantitative Systems Biomedical Scientists that participate in our program through several interactive components, including a Seminar Series in Quantitative Biology and Physiology, Student-Faculty Science-Curriculum Retreats, Monthly Dinners and Journal Clubs. In summary, our intent is to produce integrated, quantitative, and systems oriented biomedical scientists that will assume leadership positions in the life science communities of academic institutions (e.g., universities and teaching hospitals) and industry. PERFORMANCE SITE ========================================Section End===========================================