CEA in CTN: Bup/Nal treatment for opioid addicted youth

国家药物滥用治疗临床试验网络(CTN)目前正在进行的一项临床试验正在测试丁丙诺啡/纳洛酮促进的康复(BUP/NAL)对阿片依赖青少年/青壮年的有效性。BUP/NAL与心理社会治疗相结合已被证明可以改善成人的治疗结果。这种新的联合疗法为阿片依赖的年轻人带来了希望，他们的人数一直在增加，治疗或康复的前景非常渺茫。鉴于BUP/NAL最近已被批准用于成瘾治疗，量化这一新干预的成本效益将是这一新干预最终成功传播的关键。该议定书的具体目的是：(1)通过分析治疗的医疗成本、成本效益和成本效益，对丁丙诺啡/纳洛酮促进的阿片依赖青少年/青壮年康复进行全面的经济分析。(2)说明临床试验中药物滥用干预措施的经济分析方法和 促进CTN网络中的其他调查人员复制这些方法。这项研究的长期目标是(1)提供信息，以促进有效的治疗方案 (2)推广和推广药物滥用治疗临床试验中的经济评估方法，使其与评估有效性的方法一样严格。CTN是实现这些目标的理想环境，因为CTN提供了可在实践中测试这些方法的临床试验池、联网的研究人员组和广泛参与的社区治疗提供者，这些提供者努力提高治疗提供的经济效率。

One clinical trial currently underway in the National Drug Abuse Treatment Clinical Trials Network (CTN) is testing the effectiveness of Buprenorphine/Naloxone-facilitated rehabilitation (Bup/Nal)in opioid dependent adolescents/young adults. Bup/Nal in combination with psychosocial treatment has already been shown to improve treatment outcomes in adults. This new combined therapy offers hope for opiate dependent young people who have been growing in number and have very few prospects for treatment or recovery. Given that Bup/Nal has recently been approved for addiction treatment, quantifying the cost-effectiveness of this new intervention will be critical to the ultimate success of the diffusion of this new intervention. The specific aims of this protocol are to: (1) Perform a comprehensive economic analysis of buprenorphine/naloxone-facilitated rehabilitation for opioid dependent adolescents/young adults by analyzing medical costs of treatment, cost-effectiveness, and cost-benefits. (2) Illustrate the methods for economic analysis of substance abuse interventions in a clinical trial and facilitate replication of these methods by other investigators in the CTN network. The long-term objectives of this study are to (1) provide information to promote efficient treatment options for opioid dependent youth; and (2) advance and disseminate the methods of economic evaluation in clinical trials of substance abuse treatment to the point where they are as rigorous as the methods for evaluating effectiveness. The CTN is an ideal setting to meet these objectives because the CTN provides a pool of clinical trials from which to test these methods in practice, a networked set of researchers, and a broad set of participating community treatment providers that strive to improve the economic efficiency of treatment delivery.