Language and Motor Interactions in Parkinson's Disease

描述(由申请人提供)：本项目的中心目标是调查帕金森氏病(PD)患者语言需求增加对言语产生的影响。言语障碍在帕金森病中很常见；然而，对言语产生的研究主要集中在知觉特征上，而不是在言语障碍背后的复杂发音运动上。此外，尽管帕金森病患者在较长的发音过程中语音清晰度明显下降，但在这一群体中，很少有关于语音运动学的研究通常是基于音节、非单词或单词水平的产生任务。为了了解言语活动是如何受到言语交际的影响的，我们有必要考虑话语的语言结构和目标。因此，将从15名帕金森病患者和15名年龄和性别匹配的神经学正常成年人那里收集上唇、下唇和下巴的关节运动数据，这些任务的长度和语言复杂性各不相同。将分析言语运动控制的测量、语言评估的行为数据以及对言语清晰度的感知评估，以帮助全面了解PD是如何影响沟通的。这项工作将对理解与语音产生相关的神经过程具有重要意义，也将对帕金森病的诊断和治疗方法具有重要意义。

DESCRIPTION (provided by applicant): The central aim of this project is to investigate the effects of increased linguistic demands on speech production in individuals with Parkinson's disease (PD). Speech disturbances are common in PD; however, studies of speech production have primarily focused on perceptual characteristics, instead of on the complex articulatory movements underlying the speech disorder. Furthermore, although a decrease in speech intelligibility is evident during longer productions in individuals with PD, the few studies of speech kinematics in this population were generally based on syllable, non-word, or word-level production tasks. In order to understand how speech movements are affected by PD, it is essential to take into account the linguistic structure and goals of the utterance. Therefore, articulatory movement data from the upper lip, lower lip, and jaw will be collected from 15 individuals with PD and 15 age- and sex-matched neurologically normal adults during speaking tasks that vary in length and linguistic complexity. Measures of speech motor control, behavioral data from language assessments, and perceptual evaluations of speech intelligibility will be analyzed in order to contribute to a comprehensive profile of how communication is affected by PD. This work will have significance for understanding the neural processes related to speech production, and will also have important implications for diagnostic and therapeutic approaches to PD.