Research Training-Genetics of Substance Abuse

描述(由申请人提供)： 这项提案正在通过机构培训赠款寻求支持，以支持一项旨在培训博士后和博士后研究员的培训计划，这些博士后研究员将从事专注于研究基因对药物滥用的影响的研究生涯。IBG的教职员工是杰出的和积极的研究，IBG的科学家已经积极从事了超过35年的药物滥用的遗传影响的研究。与药物滥用有关的重大研究项目目前正在人类和动物行为遗传学方面进行。生物计量遗传技术的应用和数量性状基因座方法的发展使得控制复杂多基因性状的基因定位成为可能。来自这种分析的信息，以及神经化学、神经药理学和分子遗传学研究，正被用于试图提供与行为相关的基因功能的理解。设施可用于人类、小鼠和线虫模型的基因图谱研究，小鼠和线虫的行为和生化研究，以及生物计量分析。 请拨资金支持4名博士后和2名博士后实习生。博士前实习生获得合作学术单位的博士学位和行为遗传学认证。培训计划中的学术要求包括行为遗传学、定量和生物测定遗传学、理论和基于计算机的统计学、分子遗传学、负责任的研究行为以及行为和临床表型课程的培训。根据学位授予学术单位的不同，附加要求也有所不同。研究经验是培训不可或缺的一部分。博士后实习生还会攻读正规的课程，强调个人研究以及分子和数量行为遗传学方面的能力。正在筹备的其他活动包括：监督学生和/或技术人员，主办研讨会演讲者，客座演讲，以及强制参加关于负责任的研究行为的课程和每周一次的期刊俱乐部。

DESCRIPTION (provided by applicant): This proposal is seeking support, via an institutional training grant, for a training program that is geared towards training pre- and postdoctoral fellows who will pursue research careers that focus on the study of genetic influences on substance abuse. The IBG faculty is distinguished and active in research and IBG scientists have actively pursued studies of genetic influences on substance abuse for over 35 years. Major substance abuse-related research projects are now in progress in both human and animal behavior genetics. The application of biometrical genetic techniques and the development of quantitative trait loci methods allow the mapping of genes that regulate complex polygenic traits. Information from such analyses, along with neurochemical, neuropharmacological, and molecular genetic studies, are being used in attempts to provide an understanding of gene function related to behavior. Facilities are available for gene mapping studies in human, mouse and nematode models, behavioral and biochemical studies in mice and nematodes, and biometrical analyses. Funds are requested to support 4 predoctoral and 2 postdoctoral trainees. Predoctoral trainees receive doctorate degrees from a cooperating academic unit and certification in behavior genetics. Academic requirements in the training program include training in behavior genetics, quantitative and biometrical genetics, theoretical and computer-based statistics, molecular genetics, responsible conduct of research, and courses on behavioral and clinical phenotypes. Additional requirements vary according to the degree granting academic unit. Research experience is an integral part of training. Postdoctoral trainees also pursue a formalized program that emphasizes individual research as well as competence in molecular and quantitative behavior genetics. Other activities in their preparation include: supervision of students and/or technicians, hosting of seminar speakers, guest lecturing, and mandatory attendance in a course on the responsible conduct of research and a weekly journal club.