CELLULAR AND MOLECULAR NEUROSCIENCE OF SENSORY SYSTEMS

描述（来自申请人摘要）：该培训计划的目标是为有前途的研究生和医学学生，博士后和医学住院研究员在感觉系统的细胞和分子神经科学方面的成功事业做好准备。这个项目源于对塑造我们所有感官功能的基本原则的综合训练的好处，并以以下概念框架为指导：(1)人体的感觉系统是人类健康和福祉的基本贡献者，也是疾病过程的关键基础。（II）这些神经系统具有许多共同的组织和功能核心机制，在细胞、分子和遗传水平上尤为明显。（III）共同的机制也反映在感觉病理中——特定的疾病过程通常影响多个感觉系统。（四）研究生和博士后研究培训将一系列感官系统的细胞、分子和遗传方面结合起来，将增强受训者进行创新卫生研究的能力。核心机制跨越多个感觉系统，疾病过程也是如此（例如，沙克-玛丽-图斯病、诺里病、色素性视网膜炎、亚瑟综合征、衰老和感觉衰老）。因此，有必要进行研究训练，将各种特殊感觉组织的传统边界整合在一起。拟议的培训教师由12名成员组成，他们在听觉、化学感觉、机械感觉和视觉系统方面具有专业知识。学院的研究方法包括诱变和分子遗传学、细胞和分子生物学、完整动物生理学、行为分析和临床研究。培训教师的机构资源、外部支持水平和培训历史造就了一个极好的培训环境。

DESCRIPTION (from applicant's abstract): The goal of this training program is to prepare promising graduate and medical students, postdoctoral and medical resident fellows for successful careers in Cellular and Molecular Neuroscience of Sensory Systems. This program arises from the perceived benefits of integrated training in the fundamental principles which shape the function of all of our senses and is guided by the following conceptual framework: (I) The sensory systems of the human body are fundamental contributors to the health and well-being of people and are critical substrates for disease processes. (II) These neural systems share many core mechanisms of organization and function, which are especially apparent at the cellular, molecular and genetic levels. (III) Common mechanisms are also reflected in sensory pathologies- specific disease processes often impact multiple sensory systems. (IV) Graduate and postdoctoral research training which integrates cellular, molecular and genetic aspects over a range of sensory systems will enhance the ability of trainees to conduct innovative health-related research. Core mechanisms span multiple sensory systems as do disease processes (e.g. Charcot-Marie-Tooth disease, Norrie disease, Retinitis pigmentosa, Usher's syndrome, Aging and sensory senescence). Thus, there is a need for research training, which integrates across the traditional boundaries of each special-sense tissue. The proposed training faculty consists of 12 members with expertise in the auditory, chemosensory, mechanosensory and visual systems. Faculty research approaches range from mutagenesis and molecular genetics through cell and molecular biology, to intact animal physiology, behavioral analysis and clinical research. The institutional resources, level of extramural support and training histories of the training faculty engender a superb training environment.