Pancreas cancer analysis-SF Bay Area case-control study

描述（由申请人提供）： 胰腺癌分析-旧金山湾区病例对照研究：胰腺癌（PC）是癌症死亡的第四大常见原因，在所有癌症中5年生存率最低（<5%）。国家癌症研究所发起的进度审查小组和国会已将其指定为2004财政年度国家癌症研究所的高度优先事项。总体研究目标是继续对我们在1994年至2002年进行的基于人群的PC病例对照研究进行数据分析（无代理访谈，n=532例患者，1701例对照）。使用非条件logistic回归，具体目标是：1）进行饮食（营养素能量调整），胰腺炎，糖尿病，吸烟，饮酒和女性激素使用与PC的数据分析; 2）评估目标1中的因素与先前确定的多态性（GSTT 1，GSTM 1，CYPIA 1，XRCC 1）之间的关系。本研究收集了有关每个感兴趣因素的详细数据。由于感兴趣的基因在致癌的多环芳烃和杂环胺的解毒、雌激素代谢和氧化应激损伤的DNA修复中起重要作用，因此这些基因中多态性的存在可能会改变胰腺癌与Aim 1中因子之间的关联。研究优势包括：1）已经确定的遗传多态性; 2）关于风险因素的广泛信息; 3）由哈佛大学的Walter Willett博士的小组开发的饮食问卷，该小组已经为本研究计算了大量和微量营养素; 4）大样本量允许风险因素和分子数据的组合，以确定遗传和环境因素之间可能的相互作用; 5）收集了可能与PC病因学相关的食物制备方法和维生素的数据; 6）SEER登记研究提供了完整的病例确定; 7）可以评估潜在的混杂因素和效应改变。关于可改变的危险因素的数据可能会为这种毁灭性疾病提供新的和具有挑战性的结果，对公众健康具有重要意义。

DESCRIPTION (provided by applicant): Pancreas cancer analysis-SF Bay Area case-control study: Pancreatic cancer (PC) is the fourth most common cause of cancer death with the lowest 5-year survival rate (<5%) of all cancers. It has been designated as a high priority for NCI by the NCI-sponsored Progress Review Group and by Congress for FY 2004. The overall study goal is to continue data analyses for our large population-based case-control study of PC that was conducted between 1994 and 2002 (no proxy interviews, n=532 patients, 1701 controls). Using unconditional logistic regression, the specific aims are to: 1) perform data analyses of diet (energy-adjusted for nutrients), pancreatitis, diabetes, smoking, alcohol consumption, and hormone use in women in relation to PC; and 2) to evaluate the relationships between factors in Aim 1 and previously determined polymorphisms (GSTT1, GSTM1, CYPIA1, XRCC1). Detailed data were collected for this study about each factor of interest. Because the genes of interest play an important role in detoxification of carcinogenic polycyclic aromatic hydrocarbons and heterocyclic amines, estrogen metabolism and repair of DNA damaged by oxidative stress, it is plausible that the presence of polymorphisms in these genes will alter the association between pancreatic cancer and factors in Aim 1. Study strengths include: 1) already identified genetic polymorphisms; 2) extensive information on risk factors; 3) diet questionnaire developed by Dr. Walter Willett's group at Harvard University who have computed macro and micronutrients for this study; 4) large sample size allows combination of risk-factor and molecular data to determine possible interactions between genetic and environmental factors; 5) data were collected on food preparation methods and vitamins that may be relevant in PC etiology; 6) SEER registry provided complete case ascertainment; and 7) can evaluate potential confounding and effect modification. Data on modifiable risk factors may provide new and provocative results of 3ublic health importance for this devastating disease.