Sub-millimeter Nuclear Medicine Imaging at Low Energies

描述（由申请人提供）： 拟议的研究将解决体内更高分辨率的需求 通过将辐射探测器的最新创新结合在一起来成像， 多针孔成像孔径，和重建算法， 超高分辨率断层成像系统的开发。设备 将利用硅双面条探测器（DSSD），其固有的 位置分辨率将至少比 核医学中使用的常规闪烁照相机。硅 要使用的检测器非常适合于检测低- 能量（27-35 keV）光子来自1251和1231的衰变。的能力 碘化大范围分子使得这样的系统适用于许多 特别是在小动物成像领域的应用。

DESCRIPTION (provided by applicant): The proposed research will address the need for higher resolution in vivo imaging by bringing together recent innovations in radiation detectors, multiple-pinhole imaging apertures, and reconstruction algorithms in the development of an ultrahigh-resolution tomographic imaging system. The device will utilize silicon double-sided strip detectors (DSSDs) whose intrinsic position resolution will be at least an order of magnitude better than conventional scintillation cameras used in nuclear medicine. The silicon detectors that are to be used are well-suited to the detection of the low- energy (27-35 keV) photons from the decay of 1251 and 1231. The ability to iodinate a wide range of molecules makes such a system applicable to many uses, particularly in the field of small-animal imaging.