A Meshless Two-Phase Platelet Transport Model For MPHVs

描述(由申请人提供)：该项目的总体目标是开发用于研究机械人工心脏瓣膜(MPHV)周围和下游的流动诱导的血小板动力学的计算模型。需要这种工具的基本理由是，目前的瓣膜设计产生的流动具有高剪应力、湍流波动和血液再循环区域的特征，这反过来又通过诱导血小板激活以及随后在瓣膜下游聚集和沉积来增加血栓形成的风险。其目的是开发一种双向耦合的含颗粒血液两相流模型，将后者集成到现有的三维大规模并行CFD软件中，用于非定常层流-湍流不可压缩流动的无网格模拟，并通过一系列基准试验来考察所开发技术的稳健性。第一阶段的具体目标是(1)实现和测试双向耦合的通用无网格两相流求解器，以及(2)建立与血小板动力学有关的特定模型和边界条件，然后可以在第二阶段实施和测试。

DESCRIPTION (provided by applicant): The overall objective of this project is to develop computational models for investigating flow induced platelet dynamics around and downstream of Mechanical Prosthetic Heart Valves (MPHVs). The underlying justification for the need for such a tool is the common understanding that current valve designs generate flows that are characterized by high shear stresses, turbulent fluctuations, and regions of blood recirculation, which in turn enhance the risk of thrombus formation by inducing platelet activation, and subsequent aggregation and deposition downstream of the valve. The aim is to develop a particulate-laden two-phase flow model of blood with two-way coupling, to incorporate the latter into an existing 3-D massively-parallel CFD software for grid-free simulation of unsteady laminar-turbulent incompressible flow, and to investigate the robustness of the developed technology using a set of benchmark tests. The specific aims of Phase I are (1) to implement and test a generic meshless two-phase flow solver with two-way coupling, and (2) to formulate specific models and boundary conditions that pertain to platelet dynamics, which can then be implemented and tested during Phase II.