ANTIPODES The Australian National Trial Investigating Post-Operative Deficit, Early extubation and Survival

心脏手术后的脑损伤是一种不幸但常见的并发症，发生在30-80%的患者中。虽然严重的中风并不常见（1%），但更细微的影响，如健忘或行为改变，可能会持续存在，使日常生活变得困难。人们做了许多尝试来确定大脑损伤的确切原因，但没有答案。最近，现代麻醉技术的引入，可以让病人在手术后迅速醒来，有强烈的迹象表明，它们也可能造成更少的脑损伤。我们计划测试现代麻醉的这一方面，通过比较传统方法麻醉后脑损伤的测试结果和最近让病人迅速醒来的方法。

Brain damage following cardiac surgery is an unfortunate but common complication occuring variously in 30-80% of patients. Although severe strokes are uncommon (<1%), more subtle effects such as forgetfulness or behaviour changes may persist and make daily living difficult. Many attempts have been made to identify the exact cause of the brain damage, but no answer has been forthcoming. Recently, the introduction of modern anaesthetic techniques, which allow patients to wake up quickly after the operation, have given strong indications that they may also cause less brain damage. We plan to test this aspect of modern anaesthesia, by comparing the results of tests for brain damage after anaesthesia that has been given by traditional methods and the recent method which allows patients to wake up quickly.