Training in Molecular & Genetic Epidemiology of Cancer

描述(由申请人提供)：癌症研究人员目前拥有非凡的工具来了解癌症发生的遗传和环境原因。这些研究项目的设计、执行和解释需要具有不同背景的科学家团队的投入，包括分子生物学、肿瘤学、医学、遗传学、流行病学和生物统计学。在这些领域接受跨学科教育的个人对这些团队的成功至关重要。特别是，它们可以作为完成一些最有希望的研究所需的综合工作的渠道。然而，现有培训机会的重点性质为调查人员提供了有限的机会，以获得连接这些学科的知识。 为了解决这个问题，我们建议开发一个癌症遗传和分子流行病学(GMEC)的机构间培训计划。导师和研究培训机会将来自旧金山湾区的主要学术和研究机构，包括加州大学旧金山和伯克利分校、Kaiser Permanente和北加州癌症中心。拟议的计划特别适合R25T赠款机制，因为它将培训遗传学和分子流行病学跨学科领域的科学家。更具体地说，GMEC计划将以高度互动的方式将一群来自癌症研究、分子生物学、遗传学、流行病学、生物统计学和药物基因组学的导师和学员融合在一起。该计划由专门的核心课程、额外的教育经验和有多名导师的重点研究项目来定义。每个受训人员还将被要求通过撰写一份模拟的NIH提案来扩展他们的研究经验。接受该计划培训的个人将拥有了解疾病原因的关键技能，最终为癌症的治疗和预防提供有价值的信息。

DESCRIPTION (provided by applicant): Cancer researchers are presently armed with extraordinary tools for understanding the genetic and environmental causes of carcinogenesis. The design, execution, and interpretation of these research projects require input from teams of scientists with a mixture of backgrounds, including molecular biology, oncology, medicine, genetics, epidemiology, and biostatistics. Individuals with trans-disciplinary education across these fields are crucial to the success of such teams. In particular, they can serve as the conduit for the integrated work necessary to accomplish some of the most promising research. However, the focused nature of existing training opportunities provides limited opportunities for investigators to obtain the knowledge that bridges these disciplines. To address this issue, we propose developing an inter-institutional training program in Genetic & Molecular Epidemiology of Cancer (GMEC). Mentors and research training opportunities will come from major academic and research institutions in the San Francisco Bay Area, including the University of California, San Francisco and Berkeley, Kaiser Permanente and the Northern California Cancer Center. The proposed program is uniquely suited to the R25T grant mechanism because it will train scientists in the interdisciplinary field of genetic and molecular epidemiology. More specifically, the GMEC program will blend together in a highly interactive fashion a group of mentors and trainees from cancer research, molecular biology, genetics, epidemiology, biostatistics, and pharmacogenomics. The program is defined by a specialized core curriculum, additional educational experiences, and focused research projects with multiple mentors. Each trainee will also be required to extend their research experience by writing a mock NIH proposal. Individuals trained in this program will have the skills vital to understanding the causes of disease, ultimately providing valuable information for the treatment and prevention of cancer.