Childhood Precursors to Alcohol Involvement

描述（由申请人提供）： 这个为期五年的职业发展奖的主要目标是进一步发展我在酒精参与的病因学和测量方面的专业知识（使用和问题）。 为了达到这个直接的职业目标，我将接受四个主要领域的培训：（1）反社会和酒精行为之间的关系;（2）心理生理学和酒精行为之间的关系;（3）测量酒精参与的多变量方法;（4）前瞻性纵向调查的设计和实施。 拟议的培训计划将包括完成结构化的课程和研讨会，参加会议和跨学科联盟，并定期指导专家在酒精谁专门从事方法，纵向研究设计，以及心理生理学，反社会行为和其他形式的精神病理学酒精问题的关系。 这种培训建立在我的方法学博士培训，我在精神病理学的临床培训，以及我对酒精问题的风险和保护因素的研究背景。 最终，我的长期职业目标是成为一个主要研究机构的终身教职员工，研究酒精参与的病因。 该培训计划得到了一个研究项目的补充，该项目旨在前瞻性地研究儿童酗酒的风险因素和保护因素。 将从毛里求斯岛的1，795名参与者的原始样本中收集35奥尔兹的数据，这些参与者从3岁开始进行前瞻性随访。 三类儿童期风险因素（心理生理学，气质和行为）和三类保护因素（变异酒精代谢酶等位基因，女性性别和穆斯林教养）被假设与酒精参与的各个方面。 将使用四种类型的多元统计程序（多元和典型回归、结构方程建模和潜在类分析）来评估前兆和结果变量之间的关系。 这项关于酒精问题病因学的研究的潜在重要性很大，最终可能有助于预防和治疗计划的发展。 这个职业发展奖将使我从助理研究教授过渡到独立调查员，并将给我的研究生涯的基础，在病因学和酒精参与的尺寸测量。

DESCRIPTION (provided by applicant): The primary goal of this five-year career development award is to further develop my expertise in the etiology and measurement of alcohol involvement (use and problems). To reach this immediate career goal, I will receive training in four major domains: (1) the relationship between antisocial and alcohol behavior; (2) the relationship between psychophysiology and alcohol behavior; (3) multivariate methodology for measuring alcohol involvement; and (4) the design and implementation of prospective, longitudinal investigations. The proposed training plan will include the completion of structured coursework and workshops, participation in conferences and interdisciplinary consortiums, and regular mentoring from experts in the alcohol who specialize in methodology, longitudinal research design, and the relationship of psychophysiology, antisocial behavior, and additional forms of psychopathology to alcohol problems. This training builds upon my doctoral training in methodology, my clinical training in psychopathology, and my research background on risk and protective factors for alcohol problems. Ultimately, my long-term career goal is to be a tenure track faculty member in a major research institution examining the etiology of alcohol involvement. The training plan is complemented by a research project designed to prospectively examine childhood risk factors and protective factors for alcohol involvement. Data will be collected on 35 year olds from an original sample of 1,795 participants from the island of Mauritius who have been prospectively followed since age 3 years. Three classes of childhood risk factors (psychophysiology, temperament, and behavior) and three classes of protective factors (variant alcohol metabolizing enzyme alleles, female gender, and Muslim upbringing) are hypothesized to relate to various dimensions of alcohol involvement. Four types of multivariate statistical procedures (multiple and canonical regression, structural equation modeling, and latent class analysis) will be used to assess relationships among precursors and outcome variables. The potential importance of this study regarding the etiology of alcohol problems is large and might eventually help with the development of prevention and treatment programs. This career development award will enable me to transition from an Assistant Research Professor to an independent investigator and will give me the foundation for a research career in the etiology and measurement of dimensions of alcohol involvement.