Extramural Research Facilities Construction Boswell Fis*

描述（由申请人提供）： 斯坦福大学医学院制定了一项为期20年的研究和设施开发计划，其中包括扩大现有项目和新的干细胞/癌症生物学、脑研究、心血管医学、免疫学、移植和感染研究所。作为规划的一部分，我们评估了现有的动物设施和种群，并确定了支持这一扩张的预计动物设施，即，充分利用现有设施，提高现有动物设施的质量。我们发现，老鼠和水生/两栖动物的数量正在迅速增加，但空间限制正在影响研究，并最终降低畜牧业的质量。小鼠、鱼类和青蛙是鉴定与人类疾病有关的基因和突变的主要受益者，因为它们很容易且成本低廉地被操纵，而且它们的许多基因组现在正在测序。水生/两栖物种，正在迅速成为许多复杂的基因相互作用，细胞信号传导和蛋白质加工的分子和发育生物学，神经科学和药理学研究的首选物种。该提案提出了支持斯坦福大学医学院生物医学研究扩展所需的三个领域：1）缓解适当设施的短缺，以满足棘鱼、斑马鱼和青蛙对控制水质、温度和光照的特定需求; 2）将这些设施整合成一个区域，以促进合作和畜牧业支持;（三）扩大鼠患收容区，把鱼类和青蛙从鼠患收容所移往特别为它们而设的收容所。

DESCRIPTION (provided by applicant): Stanford School of Medicine has developed a 20-year plan for research and facility development that includes expansion of existing programs and new Institutes for Stem Cell/Cancer Biology, Brain Research, Cardiovascular Medicine, and Immunology, Transplantation and Infection. As part of the planning we evaluated existing animal facilities and populations and identified the projected animal facilities to support this expansion, i.e., making the highest and best use of existing facilities and improving the quality of existing animal facilities. We found that mouse and aquatic/amphibious populations were increasing rapidly, but space constraints were affecting research and would eventually diminish the quality of animal husbandry. Mice, fish and frogs are major beneficiaries of the identification of genes and mutations linked to human diseases, because they are easily and inexpensively manipulated, and many of their genomes are now being sequenced. Aquatic/amphibious species, are rapidly becoming the species of choice for many sophisticated studies of gene interactions, cell signaling, and protein processing in molecular and developmental biology, the neurosciences and pharmacology. This proposal addresses three areas needed to support this expansion of biomedical research at Stanford University School of Medicine: 1) alleviating a shortage of appropriate facilities to accommodate the specific needs of sticklebacks, zebrafish, and frogs for controlled water quality, temperature, and light; 2) consolidating these facilities into an area to facilitate collaboration and husbandry support; 3) expansion of the rodent holding areas by removing fish and frogs from mouse facilities to facilities designed for their special needs.