How Deletional and Non-Deletional Tolerance Mechanisms Integrate to Prevent Autoimmune Disease

人体每天产生数以百万计的免疫细胞来对抗感染。其中一些免疫细胞是有缺陷和危险的，因为它们会导致自身免疫性疾病，如1型糖尿病和多发性硬化症。为了消除这种风险，这些免疫细胞要么死亡，要么灭活，以防止自身免疫。我们建议研究免疫细胞死亡和失活的过程如何在健康和疾病中起作用，以便我们可以利用这些机制来治疗自身免疫。

The body produces millions of immune cells every day to fight infection. Some of these immune cells are defective and dangerous because they can cause autoimmune diseases, like Type I diabetes and multiple sclerosis. To defuse this risk, such immune cells are either caused to die or are inactivated to prevent autoimmunity. We propose to investigate how the processes of immune cell death and inactivation work in health and disease so we may harness these mechanisms to cure autoimmunity.