Rheumatic Diseases Core Center

拟成立的阿拉巴马大学伯明翰分校（UAB）风湿病核心中心（RDCC）具有独特的定位，能够将创新的、科学严谨的方法和最先进的技术应用于生物医学科学的重要问题，从而为关节炎和肌肉骨骼疾病患者的诊断和治疗奠定基础。UAB关节炎和肌肉骨骼中心（主任：Kimberly）跨学科研究的广度协同研究环境，通过六个RDCC专题工作组（神经行为医学，预防，结果和康复，实验治疗，遗传学和功能基因组学，免疫学和自身免疫，骨，软骨和结缔组织）。这些工作组的目的是提供必要的深度专门知识，以充分利用科学知识的迅速增长和技术的进步。有效和快速地将这些进展整合到RDCC的研究工作中，以及基础和临床研究人员之间的有效沟通，将通过科学充实计划进一步促进。RDCC核心设施（杂交瘤/噬菌体展示，流式细胞术和高速细胞分选，基因靶向和高分辨率成像）将提供并继续开发前沿研究所需的技术。提出了三个创新的P&F项目，促进年轻研究者的发展，每个项目都使用创新的方法来解决风湿性疾病的重要机制问题：(1)nzw衍生的小鼠狼疮耐药性；(2)抗凋亡树突状细胞在自身免疫中的作用；(3) t细胞抗原诱导的DBA/1j型胶原诱导的关节炎小鼠细胞死亡缺陷。通过行政核心的专业知识，确保科学发展，规划战略，整合工作，科学严格监督。

The proposed University of Alabama at Birmingham (UAB) Rheumatic Disease Core Center (RDCC) is uniquely positioned to enable application of innovate, scientifically rigorous approaches and state-of-the-art techniques to important questions in biomedical sciences, thereby laying the basis for advances in the diagnosis and treatment of patients with arthritis and musculoskeletal diseases. The breadth of interdisciplinary research of the UAB Arthritis and Musculoskeletal Center (Director: Kimberly) synergistic research environment that is focused through six RDCC thematic workgroups (Neurobehavioral Medicine; Prevention, Outcomes and Rehabilitation; Experimental Therapeutics, Genetics and Functional Genomics; Immunology and Autoimmunity; and Bone, Cartilage and Connective Tissue). These workg5roups are designed to provide the depth of expertise necessary to fully exploit the rapid growth in scientific knowledge and advances in technology. Effective and rapid integration of these advances into the RDCC research efforts as well as effective communication between basic and clinical investigators will be further promoted by a Scientific Enrichment Program. The RDCC Core Facilities (Hybridoma/Phage Display, Flow Cytometry and High-Speed Cell Sorting, Gene Targeting, and High Resolution Imaging) will provide and continue to develop the technologies essential for cutting edge research. Three innovative P&F projects are proposed that promote the development of young investigators, each of which use innovative approaches to address important mechanistic questions in rheumatic diseases: (1) NZW-derived Resistance to Murine Lupus; (2) The role of Apoptosis-Resistant Dendritic Cells in Autoimmunity; (3) T-Cell Antigen-Induced Cell Death Defects in Collagen-II Induced Arthritis of DBA/1j Mice. Continued scientific development, strategies planning, integration of efforts, and scientifically rigorous oversight are ensured through the expertise of the Administrative Core.