Apoe Status & Health Outcomes In Older Persons

本研究将评估成功衰老的麦克阿瑟研究的参与者，以研究载脂蛋白E（ApoE）状态如何影响最初具有高认知和身体功能的老年人的代表性样本中的认知和身体衰退，心血管疾病发病率和死亡率以及全因死亡率。这些分析是基于证据表明，ApoE 4基因型与阿尔茨海默病，心血管疾病和长寿的风险增加有关，以及更多的证据表明，它也可能与认知能力下降和功能障碍的风险有关。通过分析储存的DNA样本，获得了麦克阿瑟成功衰老队列的ApoE基因型数据。这些样本最初是在1988年研究开始时收集的。先前对采集的血液和尿液样本的分析包括胆固醇、DHEA-S、糖化血红蛋白、同型半胱氨酸和叶酸水平以及尿皮质醇和儿茶酚胺的测定。此外，麦克阿瑟数据库中的现有信息包括社会人口统计学、健康状况、健康行为、心理社会特征以及身体和认知功能的详细评估。目前已有8年随访期（1988-1996年）的数据，包括关于认知和身体功能变化模式、心血管疾病流行率和发病率以及总死亡率的详细资料。群体在性别、种族、教育程度和行为特征方面的多样性，如个人的健康行为（例如，运动、吸烟）也提供了足够数量的个体，用于分析ApoE与这些特征可能的相互作用。

This study will evaluate participants in the MacArthur Study on Successful Aging to examine how Apolipoprotein E (ApoE) status influences cognitive and physical decline, cardiovascular disease incidence and mortality, and all-cause mortality in a representative sample of older persons who initially had high cognitive and physical functioning. The analyses are based on evidence suggesting that ApoE4 genotype is associated with increased risk for Alzheimer's disease, cardiovascular disease and longevity in general as well as more suggestive evidence that it may also be associated with more general risks for cognitive decline and functional disability. Data on ApoE genotype for the MacArthur Successful Aging cohort is being obtained through analyses of stored DNA samples. These samples were originally collected in 1988 at the beginning of the study. Previous analyses of collected blood and urine samples have included assays for cholesterol, DHEA-S, glycosylated hemoglobin, homocysteine and folic acid levels as well as urinary cortisol and catecholamines. Additional, existing information int he MacArthur database includes sociodemographic, health status, health behaviors, psychosocial characteristics and detailed assessments of both physical and cognitive functioning. Data are now available for an 8-year follow-up period (1988-1996), including detailed information on patterns of change in cognitive and physical functioning, prevalence and incidence of cardiovascular disease and overall mortality. Cohort diversity with respect to gender, ethnicity, educational attainment and behavioral characteristics such as individuals' health behaviors (e.g., exercise, smoking) also provides sufficient numbers of individuals for proposed analyses of possible ApoE interactions with these characteristics.