Yale Biomedical Supercomputer

描述（由申请人提供）：该提案的宗旨是，生物医学研究的进展越来越依赖于高通量生物技术的进步(例如，自动DNA测序，mRNA表达的DNA微阵列分析，基于质谱的蛋白质组分析，以及一些用于SNP基因分型的新兴技术)，这些技术越来越受到“个人电脑”和小型部门集群的限制，耶鲁大学的研究人员无法充分及时地分析大量的结果数据。虽然最近的生物技术突破已经把我们带到了令人兴奋的系统级生物医学研究的门槛，但为了利用这些技术，耶鲁大学的研究人员将需要比他们目前所能达到的更强大的计算机，以及相应水平的技术编程和系统管理支持。拟建的耶鲁生物医学高性能计算中心将利用所要求的仪器，并将作为工作人员和物理基础设施的焦点，使计算机科学承担起生物医学研究道路上具有挑战性但可解决的问题。这一提议的优势包括非常多样化和富有成效的研究者用户基础，这将支持拟议中的中心，在过去的24年里，PI和他监管的凯克实验室展示了不断操作和维护复杂生物技术仪器的能力，并将其纳入数百名耶鲁和非耶鲁研究人员的范围，广泛的基础设施和专业知识，可以使所要求的仪器上线，并监督和支持其持续使用，耶鲁大学及其医学院的精心规划和非常坚定的支持，确保这一提议代表了一个协调和精心构思的机构响应，以提供高性能计算，推动生物医学研究向前发展。

DESCRIPTION (provided by applicant): The tenet of this proposal is that progress in biomedical research is increasingly dependent upon high throughput biotechnological advances (e.g., automated DNA sequencing, DNA microarray analysis of mRNA expression, mass spectrometric-based proteome profiling, and several emerging technologies for SNP genotyping) that are increasingly limited by the inability of the "personal computers" and small departmental clusters available to Yale investigators to adequately and timely analyze the enormous volume of the resulting data. While recent biotechnological breakthroughs have brought us to the exciting threshold of systems level biomedical research, to take advantage of these technologies Yale investigators will need far more powerful computers than are now within their reach and a commensurate level of technical programming and systems administration support. The proposed Center for High Performance Computation in Biomedicine at Yale would utilize the requested instrumentation and would serve as a focal point for the staff and physical infrastructure needed to bring computer science to bear on challenging, yet amenable problems that stand in the way of biomedical research. The strengths of this proposal include the very diverse and productive investigator user base that would support the proposed Center, the demonstrated ability over the last 24 years of the PI and the Keck Laboratory he oversees to continually operate and maintain sophisticated biotechnological instrumentation and to bring it within reach of hundreds of Yale and non-Yale researchers, the extensive infrastructure and expertise that is available to bring the requested instrumentation on-line and to oversee and support its continuous use, and the careful planning and very firm support of both Yale University and its School of Medicine to ensure that this proposal represents a coordinated and well conceived institutional response to the challenge of providing the high performance computing needed to drive biomedical research forward.