Neuropathology Core

神经病理学核心（核心C）的主要目标是安排和执行尸检，并提供前瞻性尸检临床核心招募的受试者的神经病理学诊断，并维持一个具有良好特征的死后人脑组织库（脑资源中心），用于帕金森病（PD）和路易体病（LBD）的病因学和基本机制的研究。这些组织将是必不可少的，以验证的假设和观察所产生的细胞生物学和生化研究， 在项目1-4中提出的基因工程小鼠。核心C还将维护和配备人员 组织学/免疫细胞化学和体视学实验室，以支持和促进与项目1-4中描述的PD研究相关的人类和实验小鼠模型的形态学评估。最后，核心的工作人员将培训基础研究人员和临床神经科学家在临床和神经病理学问题相关的PD。核心C的工作人员在安排和进行尸体解剖、解剖和准备 人脑组织，用于神经退行性疾病的研究方案、神经病理学诊断、形态学研究和定量形态测量。为了实现其目标，核心C将人员和维护脑资源中心（BRC），组织学/免疫细胞化学（ICC）实验室，和定量形态学/体视学设施。BRC是为研究准备的固定和冷冻脑组织的储存库，包括PD病例、其他LBD病例以及正常和患病对照。通过其许多功能和设施，核心C将支持和协调人类死后脑组织材料的加入，这些材料对于帕金森病基本机制的研究至关重要，并促进项目1-4的实验动物的形态学评估。

The chief goals of the Neuropathology Core (Core C) are to arrange and perform autopsies and provide neuropathological diagnoses in subjects enrolled by the Clinical Core for prospective autopsy, and to maintain a repository (Brain Resource Center) of well-characterized postmortem human brain tissue for investigations of the etiology and basic mechanisms of Parkinson's disease (PD) and Lewy body diseases (LBD). These tissues will be essential to validate the hypotheses and observations generated by the cell biology and biochemical studies of genetically engineered mice proposed in Projects 1-4. Core C will also maintain and staff histology/immunocytochemistry and stereology laboratories to support and facilitate the morphological assessment of human and experimental mouse models relevant to the studies of PD delineated in Projects 1-4. Finally, the staff of Core will train basic investigators and clinical neuroscientists in clinical and neuropathology issues relevant to PD. The staff of Core C has experience with the arrangement and conduction of autopsies, dissection and preparation of human brain tissues for research protocols, neuropathological diagnoses, morphological studies, and quantitative morphometry of neurodegenerative disorders. To accomplish its goals, Core C will staff and maintain the Brain Resource Center (BRC), a histology/immunocytochemistry (ICC) laboratory, and a quantitative morphometry/stereology facility. The BRC serves as a repository of fixed and frozen brain tissues prepared for research including cases of PD, other LBD, and normal and diseased controls. Through its many functions and facilities, Core C will support and coordinate the accession of human postmortem brain tissue material critical for studies of the basic mechanisms underlying Parkinson's disease and facilitate the morphological assessments of experimental animals from Projects 1-4.