Patient-oriented Research: Colon CA & Cancer Immunology

描述（由申请人提供）：本申请是作为以患者为导向的研究（K24 CA 82450）的职业中期研究者奖的竞争性更新提交的。PI是Randall F。马里兰州霍尔科姆该申请详细介绍了Holcombe博士的经验，资格和短期和长期以患者为导向的研究计划，并回顾了当前奖项支持期间的进展。详细介绍了目前和计划中的面向患者的研究.这些研究集中在以患者为导向的结肠癌研究，包括与Wnt信号通路相关的研究，阐明与结肠癌化疗相关的免疫学事件，以及白藜芦醇（葡萄皮中发现的天然化合物）的机制和潜在治疗和癌症预防作用的定义。还研究了患有炎症性肠病、患有结肠癌或处于结肠癌高风险中的患者。另外一项实验室相关研究的临床试验，最初由Holcombe博士的一位血液肿瘤学研究员设计和撰写，涉及胃癌患者的治疗。介绍了过去5年的指导活动和未来5年的指导计划。学员的成就是概述了他们目前的活动，特别是与正在进行的参与以病人为导向的研究。正在进行的指导计划包括正式的课程，基础/转化研究经验，指导临床研究试验的开发和实施，以及临床研究的实践经验。审查了当前奖项的原始目标和目的，并描述了这些目标和目的实现的程度。提供了机构支持的文件，并说明了需要通过K24机制继续提供支持的理由。

DESCRIPTION (provided by applicant): This application is submitted as a competitive renewal of a midcareer investigator award in patient-oriented research (K24CA82450). The PI is Randall F. Holcombe, MD. This application details the experience, qualifications and short- and long-term patient-oriented research plans of Dr. Holcombe, as well as reviews progress during the period of support under the current award. Details about current and planned patient- oriented research is provided. These studies are focused on patient-oriented research in colon cancer and include studies related to the Wnt signaling pathway, elucidation of immunologic events in conjunction with administration of chemotherapy for colon cancer and definition of the mechanisms and potential therapeutic and cancer preventive effects of resveratrol, a naturally occuring compound found in the skin of grapes. Patients with inflammatory bowel disease, having or at high risk for colon cancer, are also studied. An additional clinical trial with laboratory correlative studies, originally designed and written by a mentee hematology-oncology fellow of Dr. Holcombe's involves the treatment of patients with gastric cancer. Mentoring activity over the past 5 years and mentoring plans for the next 5 years are described. The accomplishments of mentees are outlined as are their current activities, especially as related to ongoing participation in patient-oriented research. Ongoing mentoring plans include formal coursework, basic/translational research experiences, instruction in the development and implementation of clinical research trials, and hands-on experiences in clinical research. The original goals and objectives of the current award are reviewed and the extent to which these have been achieved is delineated. Documentation of institutional support and justification of the need for continued support through the K24 mechanism is provided.