An Animal Biosafety Level 3 Laboratory for Stony Brook University

描述（由申请人提供）：本申请旨在为斯托尼布鲁克大学健康科学中心实验动物研究部的第一个动物生物安全3级实验室（A-BSL-3）的建设提供资金。A-BSL-3将有三个套间用于小型实验室动物的工作，一个昆虫室，和一个成像套间，相邻的房间用于大型实验室动物的工作。计划的结构将是一个16，140平方英尺。严格的BSL-3准入控制设施，用于涉及实验室动物的研究和使用特定病原体土拉热弗朗西斯菌和鼠疫耶尔森菌（均为CDC A类）的研究;结核分枝杆菌;体内毒力未知的病原体;感染人类和兽医病原体的节肢动物;或可能需要严格实验室安全的任何使用实验室动物的研究。成像套件的设计允许在A-BSL-3或A-BSL-2条件下操作，这将允许大学生物和医学科学的所有研究人员以及布鲁克海文国家实验室和冷泉港实验室的相邻机构的研究人员使用其设备。A-BSL-3将配备以下固定设备：II级生物安全柜、直通式冷藏室、通风柜、笼和机架清洗机、通风动物饲养设备和直通式高压灭菌器。A-BSL-3设施将通过美国国立卫生研究院为传染病研究提供坚实资金的第一组研究人员提供服务，以及由NIH资助的第二组研究人员。A-BSL-3设施将进一步加强斯托尼布鲁克大学和邻近机构参与传染病企业的研究人员之间的协同作用。完成时，A-BSL-3将符合联邦和州法律的所有要求，以及实验动物护理评估和认可协会推荐的标准。一个行政管理团队，由一名PI（Samuel L. Stanley）、执行委员会、设施设计和建设主任和助理主任、科学用户委员会和实验室动物资源司司长将监督设施的建设和使用。在A-BSL-3在斯托尼布鲁克大学将实现2009年的美国复苏和再投资法案的目标，以及资金机会公告恢复法有限竞争：校外研究设施改善计划（C 06），因为它将：加强公共卫生服务的行为-支持生物医学研究，支持改善动物设施的费用，以满足机构的生物医学研究需求;将绿色/可持续技术和设计方法结合起来;创造和维持美国的就业机会。

DESCRIPTION (provided by applicant): This application seeks funds for the construction of the first Animal Biosafety Level 3 Laboratory (A-BSL-3) in the Division of Laboratory Animal Research at the Health Sciences Center at Stony Brook University. The A- BSL-3 will have three suites for work with small laboratory animals, an insectary, and an imaging suite with an adjacent room for work with large laboratory animals. The planned structure will be a 16,140 ft sq. strict BSL-3 controlled-access facility for research involving laboratory animals and studies with the Select Agents Francisella tularensis and Yersinia pestis (both CDC Category A); Mycobacterium tuberculosis; pathogens of unknown in vivo virulence; arthropods infected with human and veterinary pathogens; or any investigations using laboratory animals that may require stringent laboratory security. The imaging suite is designed to allow operation under A-BSL-3 or A-BSL-2 conditions, which will permit access to its equipment by all University investigators in the biological and medical sciences and to investigators at the adjacent institutions of Brookhaven National Laboratory and Cold Spring Harbor Laboratory. The A-BSL-3 will be equipped with the following fixed equipment: Class II Biosafety Cabinets, a pass-thru cold room, fume hoods, cage and rack washers, ventilated animal housing equipment, and a pass-through autoclave. The A-BSL-3 facility will serve an initial group of investigators with solid funding in infectious disease research through the National Institutes of Health, and a secondary group of investigators, also funded by the NIH. The A-BSL-3 facility will further enhance synergy among the researchers involved in the infectious disease enterprise at Stony Brook University and adjacent institutions. At completion, the A-BSL-3 will meet all the requirements of federal and state laws, and the standards recommended by the Association for the Assessment and Accreditation of Laboratory Animal Care. An administrative management team consisting of a PI (Dr. Samuel L. Stanley), an Executive Committee, the Director and Assistant Director of Facilities Design and Construction, a Scientific Users Committee, and the Director of the Division of Laboratory Animal Resources will oversee the construction and use of the facility. The A-BSL-3 at Stony Brook University will fulfill the objectives of the American Recovery and Reinvestment Act of 2009, and the Funding Opportunity Announcement Recovery Act Limited Competition: Extramural Research Facilities Improvement Program (C06) as it will: enhance the conduct of Public Health Service-supported biomedical research by supporting the costs of improving animal facilities to meet the biomedical research needs of an institution; be built to incorporate green/sustainable technologies and design approaches; and create and maintain American jobs.