Translational Research at PENN: Advancing Cures through Interdisciplinary Science

描述(由申请人提供)：宾夕法尼亚大学计划通过在费舍尔翻译研究大楼内建造46,204平方英尺(GSF)的连续空间来推动宾夕法尼亚大学时间生物学中心的形成，从而将研究生物学和生理学的基础科学家与研究时间生物学对人类行为和健康影响的临床研究人员联合起来。Fisher大楼是一个新的405,000 GSF翻译研究设施，计划于2010年底完工，将容纳代谢、心血管生物学和癌症方面的多学科、专注于疾病的研究项目。该网站直接连接到我们的主要住院和门诊临床设施，是由宾夕法尼亚大学CTSA领导的转化性研究的焦点，通过将科学家和医生聚集在一个屋檐下，就新发现、技术和技术交流想法，真正将临床实践与临床科学相结合。由于资金限制，新的费舍尔大楼的五层研究楼层中目前只有三层获准完工。这项提案寻求资金，以完成由时间生物学中心设计并用于支助的额外一层楼。这个新的中心将团结和加强宾夕法尼亚大学杰出的跨学科科学家和医生团队，他们在时间生物学方面拥有独特的世界范围的专业知识。这种专业知识涵盖了时钟功能的基本基因和分子机制的发现，并涵盖了行为以及正常的生理和疾病机制。授予该项目使宾夕法尼亚大学能够将18名中心学者集中在一个地点，促进该中心的形成，并将该中心与费舍尔大楼的其他研究和临床项目整合在一起。总体而言，该提案将支持57名中心成员的研究任务，并提供总计1.55亿美元的积极和待定的外部支持。该中心将促进新的跨学科计划和实习生发展，针对教师招聘和指导临床应用，从而促进基础科学向改善临床护理的转变。为了支持ARRA，这个获得LEED银牌认证的项目可以在获奖和设计批准后立即开始建设。将创造430个新的就业机会，支持国家和地方企业，并承诺吸引20%-27%的少数股权公司参与。作为我们在C06建设项目中的最高机构优先事项，宾夕法尼亚大学医药公司准备为C06奖项提供1800万美元的机构支持，用于资助以外的建设项目成本，用于扩大教师招聘和项目开发，以及搬迁和新设备占用费用。

DESCRIPTION (provided by applicant): The University of Pennsylvania proposes to catalyze the formation of the PENN Center for Chronobiology through construction of 46,204 gross square feet (gsf) of contiguous space in the Fisher Translational Research Building, thereby uniting basic scientists studying biology and physiology with clinical investigators addressing the impact of chronobiology on human behavior and health. The Fisher Building, a new 405,000 gsf translational research facility scheduled for completion in late 2010, will house multidisciplinary, disease- focused research initiatives in metabolism, cardiovascular biology and cancer. Directly connected to our main inpatient and outpatient clinical facilities, the site is the focal point for translational research led by PENN's CTSA, truly integrating clinical practice with bench science by bringing scientists and physicians together under one roof to exchange ideas on new discoveries, techniques, and technologies. Because of funding limitations, only three of five research floors of the new Fisher Building are currently approved for completion. This proposal seeks funds to complete one additional floor to be designed by and used in support of the Center for Chronobiology. This new Center will unite and augment PENN's outstanding team of interdisciplinary scientists and physicians who have a unique breadth of world-wide expertise in chronobiology. This expertise spans the discovery of genes and molecular mechanisms fundamental to clock function, and encompasses behavior as well as normal physiology and disease mechanisms. Awarding this project enables PENN to coalesce 18 center scholars in a single location, catalyzing formation of the Center and integrating the Center with other research and clinical programs in the Fisher Building. Overall, the proposal will support the research mission of 57 Center members with a total of $155M in active and pending extramural support. The Center will foster new interdisciplinary program and trainee development, target faculty recruitment and guide clinical application, thereby promoting the translation of basic science to improved clinical care. In support of the ARRA, construction on this LEED Silver certified project could initiate immediately upon award issue and design approval. 430 new jobs will be created, supporting both national and local businesses, with a commitment to engaging 20-27% minority company participation. As our highest institutional priority among C06 construction projects, PENN Medicine is prepared to match the C06 award with $18 million of institutional support in construction project costs beyond those provided by the grant, for expanded faculty recruitment and program development, and in moving and new equipment occupancy expenses.