Clinical Models Workshop:Remin-Demin, Precavity, Caries

描述（由申请人提供）：至少二十年来，人们已经认识到需要更有效的模型来进行临床龋齿试验，这在2004年5月6日至7日举行的NIDCR研讨会上得到了强调。虽然已经有大量的研究集中在开发更有效的模型，这些调查一直没有接受这些临床模型评价新的龋齿预防措施的协议。因此，本次会议的总体目标是在科学界就新的、更有效的临床试验模型的可接受性达成普遍共识，该模型旨在评估龋齿预防措施对矿化或脱矿、前空穴和龋齿的影响。本次研讨会的具体目标是在科学界就以下方面达成共识：（1）确定新的、更有效的临床模型，用于对新的龋齿预防剂或措施进行临床评价;（2）描述与这些模型相关的任何特殊实验条件，以使其获得科学认可（测试持续时间、治疗依从性等）;以及（3）启动这些临床模型的过程，以被各种审查机构（如ADA和FDA）接受。实质上，这个拟议的研讨会会议旨在利用过去三年产生的科学信息，以2002年1月在苏格兰洛蒙德洛赫举行的国际龋齿临床试验共识研讨会取得的进展为基础。会议将开始一系列国家的最先进的介绍不同的临床方法，以评估remin/demin，precavitation或空化阶段的疾病。然后，大约40名应邀的龋齿学专家将在小组中工作，以解决与这些方法有关的定义问题。会议将于2005年7月3日至5日在印第安纳州印第安纳波利斯市中心的万豪酒店举行，就在年度ORCA（欧洲龋齿研究组织）会议之前。

DESCRIPTION (provided by applicant): For at least two decades it has been recognized that more efficient models are needed for the conduct of clinical caries trials and this was emphasized at the NIDCR workshop held on May 6-7, 2004. Although there has been a significant amount of research focused on the development of more efficient models for these investigations there has been no agreement on acceptability of these clinical models for evaluating new caries-preventive measures. Thus, the overall goal of this conference is to develop a general consensus among the scientific community regarding the acceptability of new, more efficient models for clinical trials designed to assess the impact of caries-preventive measures on remineralization or demineralization, precavitation and caries. The Specific Aims of this workshop-conference will be to reach a consensus in the scientific community with respect to: (1) the identification of new, more efficient clinical models for use in conducting clinical evaluations of new caries preventive agents or measures; (2) the delineation of any special experimental conditions related to these models required for their scientific acceptance (test duration, treatment compliance, etc); and, (3) the initiation of the process for these clinical models to be accepted by various review agencies such as the ADA and the FDA. In essence, this proposed workshop-conference is designed to utilize scientific information generated in the past three years to build upon the progress made at the International Consensus Workshop on Caries Clinical Trials held in Loch Lomond, Scotland in January 2002. The conference will begin with a series of state-of-the-art presentations on different clinical methodologies to assess remin/demin, precavitation or cavitation stages of the disease. Then about 40 invited experts in cariology will work in small groups to address defined issues related to these methodologies. The meeting will be held on July 3-5, 2005 in the Downtown Marriott Hotel in Indianapolis, Indiana, immediately prior to the annual ORCA (European Organization for Caries Research) meeting.