International Conference on Complexity in Acute Illness

描述（由申请人提供）：随着医学科学进入21世纪，从数据采集、计算能力和算法开发的技术进步中产生了大量的新数据。然而，在将这些数据转化为新知识和患者护理方面存在巨大的认知和文化障碍。数学建模正在成为描述和预测复杂生物现象行为的理想方法。在急性疾病中广泛实施复杂建模的一个关键障碍是将临床医生和实验室研究人员与建模者分开的鸿沟。学术界的大部分人对这种综合方法的效用持进一步的怀疑态度，他们固守着还原论的认识论范式，尽管经过了时间的考验，但很可能证明这种认识论范式不足以征服复杂的现实。为了改善这些小组之间的合作和对话，我们建议每年召开一次题为“急性疾病复杂性国际会议”的会议。本次会议的目标是1)促进临床医生，生物科学家和建模者之间的开放交流，2)展示与急性疾病相关的生物事件复杂建模的原始研究，3)为年轻和代表性不足的研究者提供一个论坛，以展示和学习跨学科研究，4)发起标准化人类疾病建模工作的努力。5)通过在合适的科学期刊上发表重点报告来促进这些努力的科学传播。我们请求支持将于2005年9月29日至10月1日在德国科隆举行的2005年国际急性疾病复杂性会议（ICCAI 2005），现在是新成立的急性疾病复杂性学会的年度会议。我们正在借鉴前三届年会的经验（www.iccai.org）。2005年将涵盖的主题包括1)急性炎症的分子模型，2)器官功能和功能障碍，3)生物变异，以及4)循证模型的障碍。在会议之前，我们还将举办一门关于数学方法的研究生课程。在主席和联合主席的指导下，每次专题会议都包括一个由知名科学家组成的国际小组的正式报告，然后是提问和讨论。我们非常重视年轻研究人员的研讨会式演讲。科学摘要将被征求，有价值的将被选择口头或海报展示，并发表在2005年12月1日的同行评议的《重症监护杂志》上。

DESCRIPTION (provided by applicant): As medical science enters the 21st century, an enormous amount of new data is emerging from technological advances in data acquisition, computational power and algorithm development. However, there exist huge cognitive and cultural obstacles to translating this data into new knowledge, and to patient care. Mathematical modeling is emerging as a desirable approach by which to describe and predict the behavior of complex biological phenomena. A key barrier to the widespread implementation of complex modeling in acute illness is the gulf separating clinicians and bench researchers on the one hand, and modelers on the other. Further skepticism as to the utility of this integrated approach exists in large segments of academia entrenched in a epistemological paradigm of reductionist that, although time tested, may well prove insufficient to conquer the complex reality. To improve collaboration and dialog among these groups, we propose a yearly meeting entitled "International Conference on Complexity in Acute Illness". The goals of this conference are to 1) facilitate open exchange among clinicians, biological scientists, and modelers, 2) present original research in complex modeling of biological events relevant to acute illness, 3) provide a forum for young and underrepresented investigators to present and learn from interdisciplinary research, 4) launch an effort to standardize modeling efforts in human disease, and 5) promote scientific diffusion of these efforts by the publication of highlight presentations in a suitable scientific journal. We request support for the 2005 International Conference in Complexity in Acute Illness (ICCAI 2005), now the annual meeting of the newly incorporated Society for Complexity in Acute Illness, to be held September 29-October 1, 2005 in Cologne, Germany. We are building on the experience of three prior annual conferences (www.iccai.org). Themes to be covered in 2005 include 1) molecular modeling of acute inflammation, 2) organ function and dysfunction, 3) biological variability, and 4) obstacles to evidence-based modeling. We will also hold a postgraduate course on mathematical methods prior to the conference. Each thematic session, under the direction of a chair and co-chair, includes formal presentations by an international group of established scientists, followed by questions and discussion. We put a strong emphasis on seminar-type presentations by young researchers. Scientific abstracts will be solicited and meritorious ones selected for oral or poster presentations, and published in the December 1, 2005 issue of the peer reviewed Journal of Critical Care.