Ensemble Neural Monitoring and Saccadic Control

描述（由申请人提供）：导师研究计划的总体目标是阐明调节跳眼运动启动和监测其后果的神经机制。研究人员记录了猕猴在执行停止信号任务时的额视场（FEF）和辅助视场（SEF）的整体神经活动。这项任务允许识别控制扫视的神经信号和监视表现的神经信号。本项目的具体目标是研究FEF中运动相关信号如何协调以控制扫视启动，以及SEF中的性能监测信号如何影响FEF以影响行为调整。这些目标将通过同时记录FEF和SEF内部和之间的多个神经元来实现。这一建议的优势在于，在一个具有强大理论基础和完善的眼运动系统解剖学和生理学的可处理的行为范式中，对执行控制的假设奠定了基础。训练目标是培养行为控制认知理论方面的专业知识，以及收集和分析皮层区域同时记录的神经元数据的方法。

DESCRIPTION (provided by applicant): The overall goal of the preceptor's research program is to elucidate the neural mechanisms that regulate the initiation and monitor the consequences of saccadic eye movements. Ensemble neural activity will be recorded from the frontal eye field (FEF) and supplementary eye field (SEF) of macaque monkeys performing a stop-signal task. This task permits identification of neural signals that control saccades and neural signals that monitor performance. The specific goals of this project are to investigate how movement-related signals in FEF are coordinated to control saccade initiation and how performance monitoring signals in SEF influence FEF to effect behavioral adjustments. These goals will be achieved by recording multiple neurons simultaneously within and across FEF and SEF. The strength of this proposal is the grounding of hypotheses about executive control in a tractable behavioral paradigm with a strong theoretical foundation and the well-established anatomy and physiology of the ocular motor system. The training goal is to develop expertise in cognitive theories of behavioral control and in methods of collecting and analyzing data from simultaneously-recorded neurons across cortical areas.