ZEBRAFISH INTERNATIONAL RESOURCE CENTER

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。描述（由申请人提供）：斑马鱼已经成为研究脊椎动物发育和遗传学的首选生物。强大的技术可以有效地产生和恢复斑马鱼突变，影响调节发育模式、器官发生、生理和行为的基因。近年来的研究进展使研究转基因斑马鱼和反义寡核苷酸的基因功能变得容易。许多这些基因的功能在脊椎动物群体中是保守的。因此，对斑马鱼突变的分析提供了对包括人类在内的其他脊椎动物基因功能的见解。ZIRC是一个为研究界提供动物、材料和服务的资源库。本提案寻求持续的资助，以便：1)为斑马鱼遗传资源和研究材料提供一个集中的存储库；2)提供咨询和病理服务；3)发展改良的斑马鱼养殖方法。这些材料、服务和信息将广泛地提供给研究界。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): Zebrafish has emerged as a premiere organism to study vertebrate development and genetics. Powerful techniques allow efficient generation and recovery of zebrafish mutations affecting genes that regulate developmental patterning, organogenesis, physiology, and behavior. Recent advances make it easy to study gene function in transgenic zebrafish and with antisense oligonucleotides. The functions of many of these genes are conserved among vertebrate groups. Thus, analysis of zebrafish mutations provides insights into gene function in other vertebrates, including humans. The ZIRC has been established as a repository that provides animals, materials, and services to the research community. This proposal seeks continued funding to: 1) provide a centralized repository for zebrafish genetic stocks and research materials; 2) provide consultation and pathology services; and 3) develop improved zebrafish husbandry methods. These materials, services, and information will be made widely available to the research community.