Kansas Mental Retardation and Developmental Disabilities Research Center (MRDDRC)

描述(由申请者提供)：为堪萨斯州智力障碍和发育障碍研究中心(MRDDRC)的竞争性更新申请五年的核心支持。堪萨斯MRDDRC现已进入第39个年头，它在产生针对精神发育迟滞和相关继发性疾病的原因、预防和治疗的高效行为干预措施，以及描述典型和非典型发育的潜在生物学基础知识方面发挥了重要的国际作用。自成立以来，该中心一直支持行为和生物学研究的平衡组合。在这一丰富历史的基础上，该中心未来的独特贡献将是开发生物知情的行为和药物干预和治疗方法。堪萨斯州MRDDRC的使命是支持与智力低下的原因和预防有关的高质量基础和应用研究，以及相关继发性疾病和相关发育障碍的预防和补救。为了实现这一使命，堪萨斯州MRDDRC旨在实现三个目标。首先，开发和支持与中心使命直接相关的新的跨学科基础和应用研究计划，将堪萨斯中心的科学家聚集在一起，并促进与其他机构的研究人员的合作项目。第二，提供具有成本效益、具有科学生产力的最先进的核心服务、资源和设施，以直接提高中心研究人员及其合作者所产生的科学的质量和影响。第三，为规划、开发、管理、协调和传播与中心相关的研究活动提供高效、经济高效的系统。堪萨斯州MRDDRC的研究计划围绕四个综合主题领域组织，每个领域都反映了一个对MRDD至关重要的一般主题，以及我们目前努力的科学方向和优势。这些主题是：1)语言、沟通和智力落后的认知；2)智力落后的风险、预防和干预；3)智力落后的神经生物学；4)早期发育的细胞和分子生物学。为协调和支持76名调查人员和75个与这些主题有关的研究项目的研究活动，拟设立四个核心单位：a)沟通和管理；b)生物行为测量；c)研究设计和分析；d)综合成像。

DESCRIPTION (provided by applicant): Core Support for five years is requested for the competitive renewal of the Kansas Mental Retardation and Developmental Disabilities Research Center (MRDDRC). The Kansas MRDDRC, now in its 39th year, has played a major international role in generating highly effective behavioral interventions aimed at the causes, prevention, and treatment of mental retardation and related secondary conditions, and in delineating basic knowledge of the underlying biology of typical and atypical development. Since its inception, the center has supported a balanced portfolio of behavioral and biological research. Building on this rich history, a unique contribution of the center in the future will be the development of biologically informed behavioral and pharmacological intervention and treatment approaches. The mission of the Kansas MRDDRC is to support high quality basic and applied research relevant to the causes and prevention of mental retardation and the prevention and remediation of associated secondary conditions and related developmental disabilities. To achieve this mission, the Kansas MRDDRC is designed to accomplish three objectives. First, to develop and support new interdisciplinary basic and applied research initiatives directly relevant to the center's mission, bringing together scientists across the Kansas Center as well as promoting collaborative ventures with researchers at other institutions. Second, to provide cost-effective, scientifically generative, state of the art core services, resources, and facilities that directly enhance the quality and impact of science produced by center investigators and their collaborators. Third, to provide highly efficient, cost-effective systems for planning, developing, managing, coordinating, and disseminating research activities associated with the center. The Kansas MRDDRC's research program is organized around four integrated thematic areas that each reflects a general topic central to MRDD as well as the scientific directions and strengths of our current efforts. These themes are: 1) language, communication, and cognition of mental retardation; 2) risk, prevention, and intervention in mental retardation; 3) neurobiology of mental retardation; 4) cellular and molecular biology of early development. To coordinate and support the research activities of the 76 investigators and 75 research projects associated with these themes, four core units are proposed: a) Communication and Administration; b) Biobehavioral Measurement; c) Research Design and Analysis; d) Integrative Imaging.