GKB: An Integrative Resource for Genome Biology

描述（由申请人提供）：该项目旨在创建一个称为基因组知识库（GKB）的网络访问资源。它将是人类基因组的过程级注释，围绕与人类生物学相关的分子过程的综合描述进行组织。GKB将采取一套“总结”的形式，这是一个类似于评论文章或书籍章节的领域内已知内容的简短电子摘要，由该领域的专家撰写。每个求和将与一组断言相关联，这些断言使用受控的词汇表和语法以及图表、动画和其他图形来呈现该领域的核心事实。 这组总结，包括断言和相关材料，将存储在一个关系数据库中。实验室生物学家将能够像浏览一本书一样浏览GKB，或者使用模板系统搜索断言数据库。生物信息学家将能够直接访问数据库，以便对知识库进行更复杂的搜索。该系统将与其他基因组数据库广泛连接。 具体目标： 1. 创建用于编写和编辑GKB求和的软件。 2. 创建一个数据库来存储这些求和。 3. 创建用于显示和搜索求和的网站基础结构。 4. 开发一个管理基础设施，每年编写30份新的总结，每年更新40份现有的总结。 5. 在5年内发表140份总结

DESCRIPTION (provided by applicant): This project seeks to create a web-accessible resource called the Genome KnowledgeBase (GKB). It will be a process-level annotation of the human genome, organized around integrated descriptions of molecular processes relevant to human biology. The GKB will take the form of a set of "summations", a short electronic summary of what is known in a field analogous to a review article or book chapter, and written by an expert in the field. Each summation will be associated with a set of assertions that present the core facts of the field using a controlled vocabulary and grammar, as well as diagrams, animations and other graphics. The set of summations, including assertions and associated materials, will be stored in a relational database. Bench biologists will be able to browse the GKB like a book, or search the assertion database using a templating system. Bioinformaticians will be able to access the database directly in order to perform more sophisticated searches of the knowledgebase. The system will be extensively linked with other genomic databases. Specific Aims: 1. To create software for authoring and editing GKB summations. 2. To create a database for storing these summations. 3. To create a web site infrastructure for displaying and searching summations. 4. To develop a management infrastructure for authoring 30 new summations per year, and updating 40 existing summations per year. 5. To publish 140 summations over the course of 5 years