Language and Motor Interactions in Parkinson's Disease

描述（由申请人提供）：该项目的中心目标是调查帕金森病（PD）患者语言需求增加对语音产生的影响。言语障碍在PD中很常见;然而，言语产生的研究主要集中在感知特征上，而不是在言语障碍的基础上的复杂发音运动上。此外，虽然语音清晰度下降是明显的，在较长的生产过程中，个人与PD，在这个人口中的语音运动学的几项研究一般是基于音节，非字，或字级的生产任务。为了了解PD如何影响言语运动，必须考虑话语的语言结构和目标。因此，发音运动数据从上唇，下唇，和下巴将收集15个人与PD和15个年龄和性别匹配的神经正常的成年人在说话的任务，不同的长度和语言的复杂性。言语运动控制的措施，从语言评估的行为数据，和言语清晰度的感知评估将进行分析，以有助于沟通是如何受到PD的影响的全面配置文件。这项工作将有意义的理解相关的语言产生的神经过程，也将有重要的意义，诊断和治疗方法PD。

DESCRIPTION (provided by applicant): The central aim of this project is to investigate the effects of increased linguistic demands on speech production in individuals with Parkinson's disease (PD). Speech disturbances are common in PD; however, studies of speech production have primarily focused on perceptual characteristics, instead of on the complex articulatory movements underlying the speech disorder. Furthermore, although a decrease in speech intelligibility is evident during longer productions in individuals with PD, the few studies of speech kinematics in this population were generally based on syllable, non-word, or word-level production tasks. In order to understand how speech movements are affected by PD, it is essential to take into account the linguistic structure and goals of the utterance. Therefore, articulatory movement data from the upper lip, lower lip, and jaw will be collected from 15 individuals with PD and 15 age- and sex-matched neurologically normal adults during speaking tasks that vary in length and linguistic complexity. Measures of speech motor control, behavioral data from language assessments, and perceptual evaluations of speech intelligibility will be analyzed in order to contribute to a comprehensive profile of how communication is affected by PD. This work will have significance for understanding the neural processes related to speech production, and will also have important implications for diagnostic and therapeutic approaches to PD.