Pre-doctoral Training in Integrative Vascular Biology

描述(由申请人提供)： 心血管疾病的发病机制是复杂的。然而，这一数字 接受过处理整个生物体疾病的培训的研究人员正在减少。 因此，我们建议培养能够实施一体化的科学家 结合“细胞”、“整体动物”和“人类”系统的方法。这是 只有通过应该开始的多学科合作才有可能 在博士前培训期间。因此，我们开发了一种跨学科 哈佛大学综合血管生物学(IVB)博士前培训计划 北卡罗来纳大学，其既定目标是激励学生 协作。为了鼓励这种多学科的方法，我们需要 学生要有两位辅导员。每年四名实习生将成为 从已入读系系课程的研究生中挑选，并 北卡罗来纳大学的课程。增加学生选择导师的自由，以及 为了将他们团结成一个IVB小组，我们将为他们提供长达三年的支持。 IVB项目由全校范围的分子项目管理 生物学和生物技术。病理学教授前田信约博士 实验室医学，是主任。论文导师是教职员工。 (来自北卡罗来纳大学三所学校和一所学院的12个部门)，具有强大的 致力于通过血管生物学相关研究进行博士前培训 在分子、细胞和整个有机体水平上，从动物 从模特到人类病人。与之配套的培训队伍包括 北卡罗来纳大学和附近机构的临床教师和个人 研究三角地区，主要维持活跃的实验室 博士后。我们的教员之间已经进行了广泛的合作 多学科博士前一体化培养的存在与机制 血管生物学已经到位并发挥了作用。申请的资金将 允许我们正式和扩展我们的IVB计划，并实施 通过确保受训者在不止一项研究中进行研究来进行小组辅导 实验室。凭借其在血管生物学研究方面的杰出历史，其 强大的研究团队，以及它在动物模型研究中的实力， IVB项目为多学科培训提供了良好的环境 博士前学生。

DESCRIPTION (provided by applicant): The pathogenesis of cardiovascular diseases is complex. Yet the number of investigators trained to deal with whole organism diseases is decreasing. Accordingly, we propose to train scientists capable of implementing integrated approaches combining "cellular", "whole animal" and "human" systems. This is only possible through multidisciplinary collaborations that should begin during predoctoral training. We have therefore developed an interdisciplinary program for predoctoral training in Integrative Vascular Biology (IVB) at the University of North Carolina with the stated goal of stimulating students to collaborate. To encourage this multi-disciplinary approach, we require students to have two complementing advisors. Four trainees a year will be selected from graduate students already enrolled in departmental programs and curricula at UNC. To increase the students' freedom in choosing advisors, and to unite them as an IVB group, we will support them for up to three years. The IVB Program is administered by the campus-wide Program for Molecular Biology and Biotechnology. Dr. Nobuyo Maeda, Professor of Pathology and Laboratory Medicine, is Director. The thesis advisors are faculty members (from 12 Departments in three Schools and one College at UNC), with a strong commitment to predoctoral training through vascular biology related research at the molecular, cellular, and whole organism levels ranging from animal models to human patients. The complementing training faculty includes clinical faculty and individuals at UNC and nearby Institutions in the Research Triangle area who maintain active laboratories mainly with postdoctoral students. Extensive collaborations among our faculty already exist and the mechanism of multidisciplinary pre-doctoral training in integrated vascular biology is already in place and functional. The requested funding will allow us to formalize and expand our IVB Program and implement the concept of group-mentoring by ensuring that trainees carry out their research in more than one laboratory. With its outstanding history in vascular biology research, its strong group of investigators, and its strength in animal model studies, the IVB Program offers an outstanding environment for multidisciplinary training of predoctoral students.