Physiological Adaptations to Exercise in Burned Children

描述 （申请人摘要）苏曼博士的长期职业目标和兴趣是 了解适应性在心血管中发生的机制， 肺和骨骼肌系统对运动的反应。 大体上，他 预见自己将在生理学领域建立一个科学的研究生涯 并将运动作为预防功能性残疾的干预工具， 疾病 他的近期职业目标包括研究适应 严重烧伤儿童的运动。 目前，苏曼博士 建议在德克萨斯大学医学分支继续他的研究 和施里纳儿童医院，与大卫N. 作者声明：Dr.沃尔夫和丹尼尔L.特拉伯 研究：The 对严重烧伤的生理反应包括持续的和 广泛的骨骼肌痉挛和虚弱，导致身体 容量 对于非烧伤个体，运动训练会诱导适应， 包括改善心血管（CV）和肌肉功能。 然而，在这方面， 目前，运动是否能使烧伤儿童产生这些适应性， 未知 更好地理解运动训练的适应性是 重要的和相关的烧伤，其中改变心血管和 肌肉功能是恢复体力活动的主要障碍， 日常生活 这项拟议中的研究将检验一个假设，即锻炼， 严重烧伤的儿童，将通过增加 心脏功能、氧摄取和利用以及骨骼肌质量。 具体目标1将评估CV和骨骼肌的减少是否 严重烧伤儿童的心脏功能受损 性能和骨骼肌氧化功能和降低浓度 肌球蛋白重链 具体目标2将评估受损害的 运动训练可改善心血管水平和肌肉功能。 具体目标3将评估是否给予合成代谢药物 （氧雄龙）烧伤的儿童将进一步加强运动的效果 对CV和骨骼肌功能的影响。 我们期待这些具体目标 作为未来治疗和长期研究的跳板 烧伤儿童的康复。

DESCRIPTION (Applicant's abstract) Dr. Suman's long-term career goals and interests are to understand the mechanism(s) by which adaptations occur in the cardiovascular, pulmonary and skeletal muscle systems in response to exercise. Broadly, he foresees himself establishing a scientific investigative career in physiology and using exercise as an interventional tool against functional disability and disease. His immediate career goals involve investigating the adaptations to exercise that occur in severely burned children. Currently, Dr. Suman proposes to continue his research at the University of Texas Medical Branch and Shriners Hospitals for Children, in collaboration with Dr. David N. Herndon, Dr. Robert R. Wolfe and Dr. Daniel L. Traber. Research: The physiological response to a severe burn injury includes a persistent and extensive skeletal muscle catabolism and weakness that leads to a low physical capacity. In non-burn individuals, exercise training induces adaptations that include improvement of cardiovascular (CV) and muscle function. However, whether exercise confers these adaptions in burned children in currently unknown. A better understanding of the adaptations to exercise training is important and relevant in burns, where alterations in cardiovascular and muscle function are major obstacles in the return to physical activities of daily living. The proposed study will test the hypothesis that exercise, in severely burned children, will improve CV and muscle performance by increasing cardiac function, oxygen uptake and utilization, and skeletal muscle mass. Specific Aim 1 will assess whether decreases in CV and skeletal muscle function in severely burned children are due to compromised cardiac performance and skeletal muscle oxidative function and decreased concentration of myosin heavy chain. Specific Aim 2 will assess whether the compromised level of CV and muscle function will be improved with exercise training. Specific Aim 3 will assess whether administration of an anabolic agent (oxandrolone) to burned children will further enhance the effects of exercise on CV and skeletal muscle functional capacity. We expect these Specific Aims to serve as a springboard for future studies in the treatment and long-term rehabilitation of burned children.