FSH and female ageing

该项目将验证一项建议，即老年女性卵泡刺激素（FSH）水平的上升直接加速生殖功能衰竭和骨质流失，这是由于生育延迟和人口老龄化导致的重大公共卫生问题。我们开发了一种独特的小鼠模型，FSH水平升高导致女性过早不孕。我们现在将使用这个模型来确定高FSH对卵巢和子宫功能的直接影响，以及随年龄增长的骨质流失。

This project will test the proposal that rising follicle-stimulating hormone (FSH) levels in ageing females directly accelerate reproductive failure and bone loss , major public health issues due to delayed childbearing and our rising ageing population. We have developed a unique mouse model with elevated FSH levels that cause premature female infertility. We will now use this model to determine the direct effects of high FSH upon ovarian and uterine function, as well as bone loss with age.