Training Program in Quantitative Biology and Physiology

描述(由申请者提供)：这项建议寻求五年的支持，以继续我们新设立的名为定量生物学和生理学(QBP)的培训计划。我们的使命是培养具有以下能力的博士研究科学家：(1)对分子生物学、细胞生物学和生理学的基本原理有定量的了解；(2)将现代方法与生物学和生理学相结合的能力；(3)将基于机械的建模技能与生物和物理系统相结合的能力；以及(4)通过跨系统或过程的多个层次(分子-细胞-组织-器官)的集成来评估紧急行为的能力。我们重建的具体目标是： *维持生物医学工程、生物、物理、化学、数学、制造工程、电气及电脑工程和机械工程的跨学科导师队伍。 *提供包括在定量分子生物学、细胞生物学和生理学方面的严格培训的课程，包括：分子和遗传系统、细胞到组织系统、组织到器官/感觉系统、尺度无关分析和建模以及多尺度测量技术。 *提供实验室轮换，以确保接触到与生物学和生理学多个尺度的问题有关的定量和系统/动力学研究技术。 *为毕业学员提供机会进行跨学科、定量、综合并与实验数据有必要联系的论文研究。 *通过互动部分建立QBP计划的独特身份和影响，包括杂志俱乐部、年度QBP研讨会、学生-教师科学-课程务虚会和每月晚宴。 我们的第一个培训赠款周期是成功的。我们正在吸引高素质的实习生，他们组织起来创造了一个赋权的身份。这些学员解决了从生物材料到神经生物学，从基因组工程和系统生物学到综合生物力学等领域的极具挑战性的问题。这些学员还持续开展活动，促进QBP计划的主题，从而丰富整个机构。我们扩大了培训导师队伍，提高了整个部门的质量，并根据经验和反馈完善了我们的管理方法。我们期待着在我们的下一个赠款周期中有机会继续这一势头。

DESCRIPTION (provided by applicant): This proposal seeks five more years of support to continue our newly established training program entitled Quantitative Biology and Physiology (QBP). Our mission is to train Ph.D. research scientists who have: (1) a quantitatively-based understanding of the principles underlying molecular biology, cell biology and physiology; (2) the capacity to synthesize modern methods with biology and physiology; (3) the capacity to synthesize mechanistic based modeling skills with biological and physical systems, and (4) the capacity to assess emergent behavior via integration across multiple levels (molecular-cellular-tissue-organ) of a system or process. The specific objectives of our renewal are: * To maintain an interdisciplinary faculty of mentors from Biomedical Engineering, Biology, Physics, Chemistry, Mathematics, Manufacturing Engineering, Electrical & Computer Engineering and Mechanical Engineering. * To provide a program curriculum that includes rigorous training in quantitative molecular biology, cell biology, and physiology inclusive of: Molecular and Genetic Systems, Cellular-to-Tissue Systems, Tissue-to-Organ/Sensory Systems, Scale-Independent Analysis and Modeling, and Multi-Scale Measurement Techniques. * To provide lab rotations that ensure exposure to quantitative and systems/dynamics research techniques relevant to problems at multiple scales of biology and physiology. * To provide graduate trainees with the opportunity to conduct thesis research that is interdisciplinary, quantitative, integrative, and necessarily linked to experimental data. * To establish a unique identity and impact of the QBP program via interactive components, including a Journal Club, Yearly QBP Symposium, Student-Faculty Science-Curriculum Retreats, and Monthly Dinners. Our first training grant cycle was successful. We are attracting high caliber trainees who have organized to create an empowering identity. These trainees address very challenging problems in areas ranging from biomaterials to neurobiology to genomic engineering and systems biology to integrated biomechanics, etc. These trainees also sustain activities that foster the themes of the QBP program so as to enrich the entire institution. We expanded our training mentor pool, improved the quality of the department as a whole, and matured our administrative approach based on experience and feedback. We look forward to the opportunity to continue this momentum during our next grant cycle.