Fox Chase Cancer Center Breast Cancer Tissue Resources

证明！_n_n， 由于缺乏足够数量的患者样本，肿瘤标志物的最终评估受到阻碍 ：缺乏足够的随访或患者信息，治疗方式的多样性，以及糟糕的 计算机化系统，以检索执行这些研究所需的病例。因此，需要的是一种 乳腺癌组织资源，能够提供足够数量的存档乳房组织，以便 研究人员根据疾病的分期、治疗方式、随访、 充分的组织学诊断、淋巴结状态、肿瘤分级和其他人口统计学数据，如年龄、绝经 地位和种族等。为了满足这些需求，我们组织了Fox Chase癌症组织资源 (FCCC-BCTR)。《中国癌症研究报告》是创建国家癌症研究所的四大支柱之一 合作乳房组织资源(NCI-CBCTR)。《联合国气候变化框架公约》-BCTR在过去八年中做出了贡献 在NCI-CBCTR数据库现有的9000例病例中，有2,859例以上。收集到的案例 包含档案石蜡组织、人口学、病理学、临床、治疗及其各自的临床数据 后续行动。最近，我们一直在开发组织微阵列，作为一种更有效的方式来提供大量的 为研究人员提供最少资源的案例。基于这一贡献，我们提出如下建议 作为《NCI-CBCTR：1：提供》的一部分，维护fccc乳腺组织资源的具体目标 组织切片和相关临床数据提供给研究人员，其应用已被推荐用于 根据业绩和内容由代表批准，并由NCI-CBCTR批准。这项工作将在合作中完成。 与NCI-CBCTR的其他资源一起使用。2：积极参与组织芯片建设 并进一步分发给其申请已建议由代表和 NCI-CBCTR。这项工作将与NCI-CBCTR的其他资源合作完成。3：至 保持足够的新案件积累，以便补充使用过的档案纸巾。4：至 构建正常乳腺组织的组织芯片并进一步分发给研究人员，其应用 已由代表和NCI.CBCTR推荐批准。5：保持足够的质量 《气候变化框架公约》中的控制。6：全面参与国家预防犯罪协调委员会的工作 合作乳腺癌组织资源并与研究评估小组7合作： 通过适当的营销活动，鼓励利用NCI-CBCTR。

PROV!_n_n, A definitive evaluation of tumor markers has been hindered by a lack of adequate number of patient's specimens and :the lack of adequate follow-up or patient information, the variability in therapeutic modalities, and poor computerization systems to retrieve the desired cases for performing these studies. Therefore, what is needed is a breast cancer tissue resource that would be able to provide archival breast tissue in sufficient amount to allow researchers to draw valid statistical conclusions, based on the stage of the disease, treatment modality, follow-up, adequate histological diagnosis, lymph node status, tumor grading and other demographic data such age, menopausal status and race among others. For answering these needs we have organized the Fox Chase Cancer Tissue Resources (FCCC-BCTR). The FCCC-CBCTR has been one of the four pillars for the creation of the National Cancer Institute Cooperative Breast Tissue Resources (NCI-CBCTR). The FCCC-BCTR has contributed during the last eight years with more than 2,859 cases to the total of 9,000 cases available in the NCI-CBCTR database. The collected cases contain the archival paraffin tissue, data on demography, pathology, clinic, treatment, and their respective clinical follow-up. Recently we have been developing the tissue microarray as a more efficient way to provide large amount of cases with minimal amount of resources to the researchers. Based on this contribution we propose the following specific aims for the maintenance of the FCCC Breast Tissue Resources as part of the NCI-CBCTR: 1: To provide tissue sections and pertinent clinical data to investigators whose applications have been recommended for approval by merit and content by REP and approved by the NCI-CBCTR. This work will be done in cooperation with the other resources of the NCI-CBCTR. 2: To actively participate in the construction of tissue microarray and further distribution to investigators whose applications have been recommended for approval by REP and by the NCI-CBCTR. This work will be done in cooperation with the other resources of the NCI-CBCTR. 3: To imaintain an adequate accrual of new cases that allows a replenishment of the used archival tissue. 4: To construct tissue microarray of normal breast tissue and further distribution to investigators whose applications have been recommended for approval by REP and by the NCI.CBCTR. 5: To maintain an adequate quality control in the FCCC-CBCTR. 6: To fully participate in the functioning of the coordinating Committee of the NCI Cooperative Breast Cancer Tissue Resource and to collaborate with the Research Evaluation Panel 7: To encourage the utilization of the NCI-CBCTR through an adequate marketing initiative.