Role of Genotype and Maternal Smoking on Brain MAO A

描述(由申请人提供)： 这是K05高级科学家奖的新申请。申请者乔安娜·S·福勒博士是一名有机化学家，是一名有机化学家，在神经科学放射性示踪剂的开发和应用方面取得了杰出的成就，包括开发18FDG，开发第一批单胺氧化酶(MAO)放射性示踪剂(以及发现吸烟者降低了大脑MAO)，以及PET在药物成瘾研究中的应用。她也是一位受欢迎的讲师，将科学和大脑成像的力量引入到毒瘾问题中。除了担任中心主任的行政职责外，她目前还在指导几名初级科学家。如果得到资助，这笔K奖金将提供60%的工资支持，这将提供至少75%的受保护时间，让她专注于理解基因、环境和行为之间的联系以及指导方面的新兴趣。为了支持这一申请，司法部同意使用从该计划中释放的资金聘请一名管理员来承担目前由福勒博士履行的行政职责。主要有两项活动：(1)研究(60%)：调查单胺氧化酶(MAO)基因和母亲吸烟对大脑MAO、脑功能和行为的影响；(2)指导(15%)：指导初级临床科学家、研究生和博士后研究员与药物滥用相关的跨学科研究。本申请中的研究利用了布鲁克海文、纽约州立大学石溪分校和纽约州立大学下州与国王学院(英国伦敦)的杰出合作者的优势，并由我们的主要能源部拨款资助，该拨款最近经过同行审查并续签了5年。这些目标的基础是迫切需要了解基因-大脑-行为关系和发育应激源在药物滥用中的作用，以及培训和激励跨学科的科学家应对药物成瘾造成的主要公共卫生问题的需要。

DESCRIPTION (provided by applicant): This is a new application for K05 Senior Scientist Award. The applicant, Dr. Joanna S. Fowler, Director of the Center for Translational Neuroimaging is an organic chemist with a distinguished record of accomplishments in the development and applications of radiotracers for the neurosciences including the development of 18FDG, the development of the first radiotracers for monoamine oxidase (MAO) (and the discovery that smokers have reduced brain MAO) and the application of PET in the study of drug addiction. She is also a sought after lecturer in bringing the power of science and brain imaging to the problem of drug addiction. She is currently mentoring several junior scientists in addition to her administrative duties as Center Director. If funded, this K award will provide 60% salary support, which will provide at least 75% protected time to focus intensely on her new interests in understanding the links between genes, the environment and behavior, and on mentoring. In support of this application, the Department has agreed to use the funds released from the Program to hire an administrator to assume the administrative duties that are now performed by Dr. Fowler. There are 2 major activities: (1) Research (60%): to investigate the role of monoamine oxidase (MAO) genotype and maternal smoking on brain MAO, brain function and behavior and (2) Mentoring (15%): to mentor junior clinical scientists, graduate students and post-doctoral fellows in trans-disciplinary research related to substance abuse. The research in this application takes advantage of outstanding collaborators at Brookhaven, SUNY Stony Brook and SUNY Downstate and Kings College (London, UK) and is funded by our major Department of Energy grant which was recently peer reviewed and renewed for 5 years. These goals build on the urgent need to understand the role of gene-brain-behavior relationships and developmental stressors in substance abuse and the need to train and inspire scientists across disciplines to respond to the major public health problems created by drug addiction.