NIMH Center for Collaborative Genetic Studies

描述（由申请人提供）：本提案是由寻找有助于精神障碍病因学的基因的需求驱动的;如果临床数据和生物材料（DNA和细胞系）在研究者之间公开共享，则更容易实现这一目标。在过去的四年中，NIMH遗传研究中心（NCGS）从血液样本中建立了13，000多个淋巴母细胞系（LCL），并处理了NIMH人类遗传学倡议PI提交的临床和基因型数据。NCGS分发了超过20，000份DNA等分试样，并将超过82份家庭，临床和基因型数据分发给更多的研究人员。这些资源的建立在加强和振兴精神障碍遗传学研究方面发挥了关键作用。Tischfield和Rice博士建议继续他们的NCGS努力，申请成为合作协议奖资助的（U24）“精神疾病合作遗传研究中心”（“中心”），提交了对RFA MH-03-003的回应。他们将继续生产LCL作为DNA的可再生来源，并将保持一个改进的，易于访问的，基于网络的临床和基因型数据生物信息学存储库，这将推动未来的研究。他们还建议对共享的公共数据集进行分析，这将增加它们对基因发现的预测价值。中心将提供项目设计咨询（例如，权力研究），候选区域的详细基因组学，血液（或其他生物制品）收集，数据分析，以及共享资源的最佳组织和使用。该中心的首要目标是满足NIMH PI的科学需求，同时尊重受试者保密性、知情同意问题和PI特权。通过鼓励和促进收集和共享生物制剂以及来自精神障碍（如精神分裂症，双相情感障碍或自闭症）受试者或家庭的临床和基因型数据，以及自己对这些数据的分析，该中心将大大加快了解这些疾病病因学中遗传成分的进展。

DESCRIPTION (provided by applicant): This proposal is driven by the need to find genes that contribute to the etiology of mental disorders; a goal more readily attained if clinical data and biological materials (DNA and cell lines) are openly shared among investigators. During the past four years, the NIMH Center for Genetic Studies (NCGS), established over 13,000 lymphoblast cell lines (LCLs) from blood samples and processed clinical and genotype data submitted by PIs of the NIMH Human Genetics Initiative. The NCGS distributed over 20,000 DNA aliquots and made more than 82 distributions of family, clinical and genotype data to a larger group of investigators. The establishment of these resources has played a critical role in enhancing and invigorating research on the genetics of mental disorders. Drs. Tischfield and Rice propose to continue their NCGS efforts with this application to become the Cooperative Agreement Award-funded (U24) "Center for Collaborative Genetic Studies on Mental Disorders" (the "Center"), submitted in response to RFA MH-03-003. They will continue to produce LCLs as a renewable source of DNA and will maintain an improved and easily accessible, web-based bioinformatics repository of clinical and genotype data that will drive future research. They also propose analyses of shared, public data sets that will add to their predictive value for gene discovery. The Center will provide consultation on project design (e.g., power studies), detailed genomics of candidate regions, blood (or other biologicals) collection, data analysis, and best organization and use of shared resources. The overriding aim of the Center will be to serve the scientific needs of the NIMH PIs, while respecting subject confidentiality, informed consent issues, and PI prerogatives. By encouraging and facilitating the collection and sharing of biologicals as well as clinical and genotype data from subjects or families with mental disorders such as schizophrenia, bipolar disorder, or autism, and its own analyses of these data, the Center will greatly accelerate progress toward understanding the inherited components in the etiology of these diseases.