CEA in CTN: Bup/Nal treatment for opioid addicted youth

目前正在国家药物滥用治疗临床试验网络（CTN）进行的一项临床试验正在测试丁丙诺啡/纳洛酮促进康复（Bup/Nal）在阿片类药物依赖青少年/年轻人中的有效性。Bup/Nal与心理社会治疗相结合已被证明可以改善成人的治疗结果。这种新的综合疗法为阿片类药物依赖的年轻人带来了希望，他们的人数一直在增加，治疗或康复的前景非常渺茫。鉴于Bup/Nal最近已被批准用于成瘾治疗，量化这种新干预措施的成本效益对于这种新干预措施的最终成功推广至关重要。本方案的具体目的是：（1）通过分析治疗的医疗成本、成本效益和成本效益，对阿片类药物依赖青少年/年轻人的丁丙诺啡/纳洛酮促进康复进行全面的经济分析。(2)说明药物滥用干预措施在临床试验中的经济分析方法， 促进CTN网络中的其他研究者复制这些方法。本研究的长期目标是（1）提供信息，以促进有效的治疗方案， 依赖阿片类药物的青年;（2）推进和推广药物滥用治疗临床试验的经济学评估方法，使其与评估有效性的方法一样严格。CTN是实现这些目标的理想环境，因为CTN提供了一个临床试验池，可以在实践中测试这些方法，一组联网的研究人员，以及一组广泛的参与社区治疗提供者，努力提高治疗的经济效率。

One clinical trial currently underway in the National Drug Abuse Treatment Clinical Trials Network (CTN) is testing the effectiveness of Buprenorphine/Naloxone-facilitated rehabilitation (Bup/Nal)in opioid dependent adolescents/young adults. Bup/Nal in combination with psychosocial treatment has already been shown to improve treatment outcomes in adults. This new combined therapy offers hope for opiate dependent young people who have been growing in number and have very few prospects for treatment or recovery. Given that Bup/Nal has recently been approved for addiction treatment, quantifying the cost-effectiveness of this new intervention will be critical to the ultimate success of the diffusion of this new intervention. The specific aims of this protocol are to: (1) Perform a comprehensive economic analysis of buprenorphine/naloxone-facilitated rehabilitation for opioid dependent adolescents/young adults by analyzing medical costs of treatment, cost-effectiveness, and cost-benefits. (2) Illustrate the methods for economic analysis of substance abuse interventions in a clinical trial and facilitate replication of these methods by other investigators in the CTN network. The long-term objectives of this study are to (1) provide information to promote efficient treatment options for opioid dependent youth; and (2) advance and disseminate the methods of economic evaluation in clinical trials of substance abuse treatment to the point where they are as rigorous as the methods for evaluating effectiveness. The CTN is an ideal setting to meet these objectives because the CTN provides a pool of clinical trials from which to test these methods in practice, a networked set of researchers, and a broad set of participating community treatment providers that strive to improve the economic efficiency of treatment delivery.