Service Core 2: Biomolecular Resource

描述(由申请人提供)：生物分子资源设施(BRF)是UTMB新重组和扩展的基础设施研究服务，包括主要用于蛋白质和多肽的种群和/或分析的五个成分核心。生物分子资源设施核心是指由NIEHS中心支持的BRF的组成部分。五个组成核心是：1)质谱学，2)肽合成，3)蛋白质化学，4)蛋白质表达和纯化，5)蛋白质组学。在过去的资助期间，这个NIEHS服务核心被称为蛋白质化学和纯化核心设施。主要的新增加包括蛋白质组学核心和质谱学核心， 以及从三项NIH/NCRR设备赠款(首席研究员A.Kurosky)获得的几项主要设备。重新组织了设施的管理结构，为NIEHS调查人员提供了更高的运营效率和更大的便利；在提供的18项服务中，有16项服务的NIEHS使用量占设施UTMB总使用量的5%至75%，具体取决于服务。这一使用量代表着NIEHS的极好回报。投资，目前约占主权财富基金总直接运营成本的10%。核心主管Alex Kurosky博士在蛋白质结构和功能以及遗传学方面拥有30多年的经验。BRF在UTMB获得美国国立卫生研究院颁发的几项重大蛋白质组学资助奖项方面发挥了重要作用，其中包括授予Kurosky博士的NHLBI蛋白质组学研究中心。由此产生的新能力反过来又提高了BRF对NIEHS中心调查人员的价值。继续支持这个扩展和重组的核心对NIEHS中心非常重要，特别是为我们的中心研究人员提供急需的蛋白质组学和质谱学技术。

Description (provided by applicant): The Biomolecular Resource Facility (BRF) is a newly re-organized and expanded infrastructure research service at UTMB that includes five component cores largely dedicated to the population and/or analysis of proteins and peptides. The Biomolecular Resource Facility Core refers to that component of the BRF that is supported by the NIEHS Center. The five component cores are: 1) Mass Spectrometry, 2) Peptide Synthesis, 3) Protein Chemistry, 4) Protein Expression and Purification, and 5) Proteomics. In the past funding period this NIEHS service core was called the Protein Chemistry and Purification Core Facility. Major new additions include a Proteomics Core and a Mass Spectrometry Core, as well as several major items of equipment obtained from three NIH/NCRR equipment grants (A. Kurosky, principal investigator). Re-organization has centralized the administrative structure of the facility, providing a higher efficiency of operation and greater convenience to NIEHS investigators; 16 of the 18 services offered have NIEHS usages ranging from 5% to 75% of the facility's total UTMB usage, depending on the service. This amount of usage represents an excellent return on NIEHS. investment, which is currently about 10% of the BRF.s total direct operating costs. The core director, Dr. Alex Kurosky, has over 30 years of experience relating to protein structure and function and to genetics. The BRF has been instrumental in UTMB's receipt of several major proteomics funding awards from NIH, including a major NHLBI Proteomics center to Dr. Kurosky. The resulting new capabilities in turn enhance the value of the BRF to NIEHS Center investigators. Continued support for this expanded and re-organized core will be very important to the NIEHS Center, especially to provide our Center investigators much-need access to proteomics and mass spectrometry technologies.