Functional characterisation of long spliced ncRNAs

基因组测序项目表明，我们只有大约3万个编码基因，这在以前被认为是太少了，无法为人类复杂性的产生提供蓝图。更令人惊讶的是，3-5%的基因组被转录，但没有被翻译成蛋白质。这些非编码rna的功能尚不清楚，但争论激烈。是垃圾吗？或者它在编程开发中扮演了一个新的关键角色？这笔拨款将直接解决这个问题。

Genome sequencing projects suggest we only have approximately thirty thousand coding genes which was previously considered to be far too few to provide the blueprint for generation of human complexity. More surprising was the discovery that 3-5% of the genome is transcribed but not translated into protein. The function of these non-coding RNAs is unknown but hotly debated. Is it junk? Or does it play a new key role in programming development? This grant will address this question directly.