EATRIGHT FOR LIFE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。美国肥胖者的数量正在增加。对于非裔美国人来说，肥胖的增加是不成比例的。例如，典型的减肥干预通常显示，与高加索人相比，非洲裔美国人的体重减轻较少。减肥可以改善胆固醇、血压、高血压风险、血糖，并可以预防2型糖尿病的发展。因此，许多非裔美国人可以从减肥中获得的好处并没有实现。使用一段时间的形成性评估，以收集有关的关键文化变量的信息，我们建议制定和实施一个文化上适当的行为干预的基础上EatRight饮食模式的体重控制。EatRight是一个基于“时间-卡路里置换”概念的12周生活方式导向的体重控制计划，强调摄入大量高体积、低能量密度食物和适量摄入高能量密度食物。我们将使用定性方法来为我们制定量身定制的饮食干预提供信息。主要结果是体重的变化，次要指标是心血管风险的标志物，包括血压、血脂、血糖和胰岛素。该项目的成功完成将导致一个广泛可用的饮食干预，并证明在非洲裔美国人的有效性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The number of obese individuals in the United States is increasing. For African Americans, the increase in obesity has been disproportionate. For example, typical weight loss interventions routinely show less weight loss for African Americans compared to Caucasians. Weight loss improves cholesterol, blood pressure, risk of hypertension, blood glucose, and can prevent the development of type 2 diabetes. Therefore, many of the benefits that African Americans could receive from weight loss are not realized. Using a period of formative assessment to gather information regarding the key cultural variables, we propose to develop and implement a culturally appropriate behavioral intervention for weight control based on the EatRight dietary pattern. EatRight is a 12-week lifestyle-oriented weight control program based on the concept of "time-calorie displacement," which emphasizes the ingestion of large quantities of high-bulk, low-energy-density foods and moderation in high-energy-density foods. We will use qualitative methodologies to inform our development of the tailored dietary intervention. The primary outcome is change in weight, with secondary measures of markers of cardiovascular risk including blood pressure, lipids, glucose, and insulin. The successful completion of this project will lead to a widely usable dietary intervention with demonstrated effectiveness in African Americans.