THE DINE STUDY - DIET INTERVENTION TO NEGATE DIABETES STUDY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Ideally, a dietary prescription would produce improvements in CVD risk profiles even with modest amounts of weight loss achieved. Achieving this ideal might be important for African American populations for 2 reasons: (1) the dietary prescription should improve overall cardiovascular health and not just one risk factor,(2) the optimal impact for improvement of cardiovascular risk may have to be achieved with lesser amounts of weight loss. The aim of this project is to characterize the physiologic effects of the DASH dietary pattern, with and without weight loss, on insulin sensitivity and selected CVD risk factors in obese African Americans. Study participants (n = 93) will be randomized to one of three, 8- week feeding protocols that include a isocaloric DASH diet, a hypocaloric DASH diet, or a hypocaloric control diet (typical American intake). This study design will allow the testing of the following hypotheses: (1) African Americans on an isocaloric DASH diet will have greater improvement in insulin sensitivity compared to African Americans on a reduced calorie, control diet; (2) African Americans on a weight reducing DASH diet will have greater improvement in insulin sensitivity compared to African Americans on a reduced calorie, control diet; and (3) the effects on insulin sensitivity of a weight reducing DASH diet will be sub-additive compared to the combined effects on insulin sensitivity of an isocaloric DASH diet and a reduced calorie control diet.