THE DINE STUDY - DIET INTERVENTION TO NEGATE DIABETES STUDY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。理想情况下，饮食处方将产生改善心血管疾病的风险概况，即使实现适度的减肥。实现这一理想可能对非洲裔美国人很重要，原因有二：（1）饮食处方应该改善整体心血管健康，而不仅仅是一个风险因素，（2）改善心血管风险的最佳影响可能必须以较少的体重减轻来实现。该项目的目的是表征DASH饮食模式的生理效应，有和没有体重减轻，对胰岛素敏感性和选定的CVD危险因素在肥胖的非洲裔美国人。研究参与者（n = 93）将被随机分配到三个为期8周的喂养方案之一，包括等热量DASH饮食，低热量DASH饮食或低热量对照饮食（典型的美国摄入量）。该研究设计将允许测试以下假设：（1）与低热量对照饮食的非裔美国人相比，等热量DASH饮食的非裔美国人将具有更大的胰岛素敏感性改善;（2）与低热量对照饮食的非裔美国人相比，体重减轻DASH饮食的非裔美国人将具有更大的胰岛素敏感性改善;和（3）与等热量DASH饮食和减少热量控制饮食对胰岛素敏感性的组合作用相比，减轻体重的DASH饮食对胰岛素敏感性的作用是次加和的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Ideally, a dietary prescription would produce improvements in CVD risk profiles even with modest amounts of weight loss achieved. Achieving this ideal might be important for African American populations for 2 reasons: (1) the dietary prescription should improve overall cardiovascular health and not just one risk factor,(2) the optimal impact for improvement of cardiovascular risk may have to be achieved with lesser amounts of weight loss. The aim of this project is to characterize the physiologic effects of the DASH dietary pattern, with and without weight loss, on insulin sensitivity and selected CVD risk factors in obese African Americans. Study participants (n = 93) will be randomized to one of three, 8- week feeding protocols that include a isocaloric DASH diet, a hypocaloric DASH diet, or a hypocaloric control diet (typical American intake). This study design will allow the testing of the following hypotheses: (1) African Americans on an isocaloric DASH diet will have greater improvement in insulin sensitivity compared to African Americans on a reduced calorie, control diet; (2) African Americans on a weight reducing DASH diet will have greater improvement in insulin sensitivity compared to African Americans on a reduced calorie, control diet; and (3) the effects on insulin sensitivity of a weight reducing DASH diet will be sub-additive compared to the combined effects on insulin sensitivity of an isocaloric DASH diet and a reduced calorie control diet.