Does Moderate Intensity Exercise Help Prevent Smoking Relapse Among Women?

说明(申请人提供)：烟草使用仍然是妇女癌症的主要、可预防的原因；然而，大约21%的妇女继续吸烟。情绪相关的戒断症状和对戒烟后体重增加的担忧是最初戒烟后复发的重要预测因素，特别是在女性中。中等强度的运动是标准戒烟治疗的安全和低成本的补充，可以通过改善情绪和减轻戒烟期间的体重担忧来帮助防止复发。之前的大规模干预试验没有发现中等强度运动的显著效果，但对这些运动计划的坚持一直很差，因此运动的效果不能与坚持计划的效果分开。相反，对照实验室研究表明，急性中等强度运动可以减少对香烟的渴望和戒断症状，但这些效果还没有经过长期或长期锻炼计划的测试。这项拟议的研究将试点研究方法，以分离出长期中等强度运动计划对健康成年女性吸烟者戒烟的影响。具体地说，我们计划在60名健康女性中比较标准戒烟治疗的效果，包括一次性短暂咨询、提供尼古丁贴片和为期8周的中等强度运动计划，以及相同标准戒烟治疗和同等接触控制的效果。将使用一些技术来提高对治疗计划的依从性，从而更有效地隔离运动的影响。这些措施包括：(1)在随机化之前有两周的磨合期；(2)在参与者随机化之前使用行为收缩；(3)现场所有锻炼的表现。戒烟结果(持续戒烟和点流行戒烟)将通过一氧化碳和唾液可替宁来验证。体力活动将通过参加监督课程进行评估。

DESCRIPTION (provided by applicant): Tobacco use continues to be the leading, preventable cause of cancer among women; however, approximately 21 % of women continue to smoke cigarettes. Mood-related withdrawal symptoms and concerns about weight-gain following cessation are significant predictors of relapse following initial cessation, especially among women. Moderate intensity exercise is a safe and low-cost adjunct to standard smoking cessation treatments that may help prevent relapse by improving mood and attenuating weight concerns during smoking cessation. Previous large-scale intervention trials have not found a significant effect for moderate intensity exercise, but adherence to these exercise programs has been poor, and therefore the effects of exercise cannot be isolated from the effects of program adherence. Conversely, controlled laboratory studies have shown that acute moderate intensity exercise can reduce cigarette cravings and withdrawal symptoms, but these effects have not been tested over the long term or with a prolonged exercise program. The proposed study will pilot research methods that will isolate the effects of a prolonged moderate intensity exercise program on smoking cessation among healthy adult female smokers. Specifically, we plan to compare the effects of a standard smoking cessation treatment, including one-time brief counseling and provision of nicotine patch plus an 8-week moderate intensity exercise program versus the same standard smoking cessation treatment plus equivalent contact control among 60 healthy women. A number of techniques will be used to increase compliance with the treatment program, thus more effectively isolating the effects of exercise. These include: (1) a two-week run-in period prior to randomization; (2) use of behavioral contracting prior to participant randomization; and (3) performance of all exercise on-site. Smoking cessation outcomes (continuous abstinence and point prevalence abstinence) will be verified by carbon monoxide and saliva cotinine. Physical activity will be evaluated by attendance at the supervised sessions.