Using population resequencing data to investigate the evolutionary role and functional impact of inversion polymorphisms

该项目将利用种群重测序数据，在超过5000人的多个种群中生成倒置多态性的高分辨率单倍型图谱。这些图谱将用于在超过100,000个个体的基因分型样本中推算反转多态性，这得益于从种群序列数据中绘制反转多态性的新算法的发展。最后，该项目将利用这张图来评估倒序的功能影响和进化作用，通过评估它们对数量性状的影响以及评估选择和种群分化的措施。

The project will use population re-sequencing data to generate high resolution haplotype maps of inversion polymorphisms in multiple human populations comprising more than 5,000 individuals. These maps will be used to impute inversion polymorphsisms in genotyped samples of more than 100,000 individuals, facilitated by development of novel algorithms for mapping inversion polymorphism from population sequence data. Finally, the project will use this map to assess the functional impact and evolutionary role of inversions, by assessing their effect on quantitative traits and assessing measures of selection and population differentiation.