AMC OPERATIONS CENTER

这项提议是将阿拉巴马大学伯明翰分校(UAB)的综合癌症中心生物统计单位作为艾滋病相关恶性肿瘤临床试验联盟(AMC)的运营、统计和数据管理中心。到目前为止，AMC已经招募了159名患者参加5个AMC方案。最近有两个方案对患者应计费用开放。另有9项议定书正在制定中。AMC运营中心向AMC提供研究设计、样本量和分析方面的统计专业知识；协调AMC的开发、提交、实施和分析；维护临床试验的数据库；对研究数据进行统计分析；管理可自由支配基金；协调从AMC参与者那里获取样本，以便捐赠给艾滋病恶性病库。在即将到来的供资期间，AMC业务中心计划在数据录入过程中增加扫描仪的使用；提高生物统计支助水平；增加使用AMC网页传播信息；并在工作人员中增加一名财务助理来管理可自由支配基金。

This proposal is for the Comprehensive Cancer Center Biostatistics Unit at the University of Alabama at Birmingham (UAB) to serve as the Operations, Statistical and Data Management Center for the AIDS-Associated Malignancies Clinical Trials Consortium (AMC). To date, the AMC has enrolled 159 patients on five AMC protocols. Two protocols have recently opened to patient accrual. An additional 9 protocols are under development. The AMC Operations Center provides statistical expertise to the AMC in the areas to study design, sample size, and analyses; coordinates the development, submission, conduct and analysis of AMC; maintains the database for the clinical trials; performs statistical analyses on study data; manages the Discretionary Fund; and coordinates the acquisition of specimens from AMC participants for donation to the AIDS Malignancy Bank. During the upcoming funding period, the AMC Operations Center plans to increase the use of scanners in the data entry process; increase the level of biostatistical support; increase the use of the AMC WEB page for the dissemination of information; and add a fiscal associate to the staff to manage the discretionary fund.