Sickle Cell Disease Research Center (SCDRC) Summer Institute/Mentoring Program

描述（由申请人提供）：镰状细胞病研究中心（SCDRC）的使命是“积极积极地参与基础研究和培训的实质性发展，以改善治疗方案或治愈镰状细胞病”。SIPID资助倡议与SCDRC项目的使命相关，因为它将利用多学科方法来增加与心脏、肺和血液疾病相关的生物医学研究中代表性不足的少数群体。该项目将资助暑期学院，让10-12名来自未被充分代表的种族和民族的参与者进一步发展他们的研究技能和知识，从而提高他们作为教员或科学家的职业发展。夏季研究所将侧重于与镰状细胞病（SCD）相关的基于基因组的生物医学研究：为基因组研究引入多学科方法，建立有关当前技术进步的广泛基础工作知识，并确定涉及现代DMA和蛋白质分析工具的未来研究项目的潜在领域。这将通过课堂教学讲座和实验室设置的实践培训来完成。我们的目标将包括：通过建立结构化的指导培训计划和导师与学员之间的长期研究合作，增加进入研究职业的种族和伦理方面服务不足的个人的数量；提高参与者的资助技巧；并确定校外研究资助机会。科学和学术活动的多样性将有助于改善来自不同背景的患者和受试者的公共卫生。研究表明，一个种族和谐的科研人员更能成功地从少数群体中招募个体进入临床研究。种族相似的医患二人组已被证明与更高的患者满意度有关，这也可能在临床研究环境中加强沟通和参与。对多样化劳动力的需求渗透到国家公共卫生研究工作的各个方面。由于少数民族承受着与hbs疾病相关的发病率和死亡率的不成比例的负担，因此迫切需要增加对hbs疾病（如镰状细胞病）的健康差异进行研究的调查人员的数量。

DESCRIPTION (provided by applicant): The mission of the Sickle Cell Disease Research Center (SCDRC) is to "actively and aggressively participate in the substantive development of basic research and training efforts to improve treatment options or cure sickle cell disease". The SIPID funding initiative is relevant to the mission of the SCDRC project because it will utilize a multidisciplinary approach to increase underrepresented minorities in Biomedical Research related to heart, lung, and blood disease. The program will fund summer institutes to enable 10-12 participants from underrepresented racial and ethnic groups to further develop their research skills and knowledge, thereby enhancing their career development as faculty members or scientists. The summer institute will focus on genomic-based biomedical research related to sickle cell disease (SCD): to introduce multidisciplinary approaches to genomic research and establish a broad base working knowledge of current technological advances and identify potential areas of future research projects involving modern DMA and protein analytical tools. This will be accomplished through classroom didactic lectures and hands-on bench training in laboratory settings. Our goals will include: increasing the number of racial and ethical underserved individuals who enter research careers by establishing a structured mentored training program and long-term research collaborations between mentors and mentees; increasing grantsmanship skills of participants; and identifying extramural research funding opportunities. Diversity of scientific and scholarly activity will be valuable in improving the public health of patients and subjects from diverse backgrounds. Studies have suggested that a racially concordant scientific staff is more successful in recruiting individuals from minority groups into clinical studies. Racially similar physician-patient dyads have been shown to be related to greater patient satisfaction in ways that may also enhance communication and participation in a clinical research setting. The need for a diverse workforce permeates all aspects of the nation's public health-related research efforts. Because minorities suffer a disproportionate burden of morbidity and mortality associated with HLBS disorders, there is a critical need to increase the number of investigators conducting research on health disparities in HLBS disorders, such as sickle cell disease.