Spatial Information Management Resources for Human Brain

描述（由申请人提供）：神经科学家和临床医生需要强大的计算机化数据和图像管理资源来处理有关大脑的新信息的上升趋势。这些资源必须全面、可获取，并能够直接与其他计算机化系统通信，而无需人工干预。经典的神经解剖学标志为整合新的和现有的大脑信息提供了一个重要的参考框架。Braininfo是一个网络资源，其中的信息是由一个全面的神经解剖学命名索引。命名法NeuroNames与美国国家医学图书馆的统一医学语言系统完全集成。它包括人类和非人类灵长类动物大脑的术语。命名法的适当部分已被纳入一个系统的神经解剖学的定义，说明结构的概念，参考非人类灵长类动物的大脑图谱。我们建议创建一个三维计算机化的人脑图谱，并将这个定义系统扩展到人脑，建立机制，使BrainInfo网站的访问者可以将数据映射到网络上的大脑图谱，并建立BrainInfo和两个最广泛的基于网络的人脑功能数据源之间的兼容性和互操作性。BrainInfo和NeuroNames的资源目标是加速获取和传播关于大脑的现有和新的科学知识。这将通过应用数字通信技术来实现，以一种适合神经科学家，临床医生和神经解剖学学生的知识结构和直观搜索策略的方式，通过Web实现有关大脑的信息的即时通信。(http地址：braininfo.rprc.washington.edu）

DESCRIPTION (provided by applicant): Neuroscientists and clinicians need powerful computerized data and image management resources to deal with the rising tide of new information about the brain. Such resources need to be comprehensive, accessible and capable of communicating directly with other computerized systems without the need for human intervention. Classical neuroanatomical landmarks provide an essential frame of reference for integrating new and existing information about the brain. Braininfo is a Web resource in which information is indexed by a comprehensive neuroanatomical nomenclature. The nomenclature, NeuroNames, is fully integrated with the Unified Medical Language System of the National Library of Medicine. It includes terminology for both the human and the nonhuman primate brain. Appropriate parts of the nomenclature have been incorporated into a system of neuroanatomical definitions that illustrates structural concepts by reference to an atlas of the nonhuman primate brain. We propose to create a 3-dimensional computerized atlas of the human brain and to extend this definitional system to the human brain, to establish mechanisms whereby visitors to the Brainlnfo website can map data into brain atlases on the Web, and to establish compatibility and interoperability between Brainlnfo and two of the most extensive web-based sources of data on human brain function. The resource objective of Brainlnfo and NeuroNames is to accelerate the acquisition and distribution of existing and new scientific knowledge about the brain. This will be accomplished by applying digital communications technology to enable immediate communication of information about the brain via the Web in a manner tailored to the knowledge structure and intuitive search strategies of neuroscientists, clinicians, and students of neuroanatomy. (http://braininfo.rprc.washington.edu)