ECAD:Enhanced Coronary Artery Disease Phantom for MRA

描述(由申请人提供)： 由于缺乏现实的心脏搏动血流模型，建立临床实用的MRA的努力受到阻碍。我们建议开发一种增强型冠状动脉疾病(ECAD)体模，供MR研究人员、开发人员和医疗设备制造商使用。ECAD将以前引入的技术的先进功能与创新的设计、材料和工艺相结合，以创造一个重现临床条件的受控环境。这将通过：1)基于临床数据开发功能心脏结构，2)将结构与先进的材料、工艺和模块化基础设施相结合，以再现心脏功能，3)验证ECAD在解剖上的准确性，以及在脉动流动条件下正确的流动模式和运动，以及4)在学术和工业环境的扩展评估中展示原型的重复性、稳定性和商业潜力。通过引入强大的基于计算机的有限元分析以及与内部数控原型硬件的CAD/CAM集成，显著改进了设计优化和制造技术。工艺技术的改进将有助于Ill阶段的商业化。商业上可用的ECAD将对开发、验证和培训医务人员使用最先进的冠状动脉疾病MRA诊断方案至关重要。

DESCRIPTION (provided by applicant): Efforts to establish MRA as clinically practical are hampered by lack of realistic beating heart flow phantom. We propose to develop an enhanced Coronary Artery Disease (eCAD) phantom for use by MR researchers, developers and medical equipment manufacturers, eCAD combines advanced features from previously introduced technology with innovative design, materials and processing to create a controlled environment which reproduces clinical conditions. This will be accomplished by: 1) developing functional cardiac structures based on clinical data, 2) combining structures with advanced materials, processing and modular infrastructure to reproduce cardiac functionality, 3) verifying eCAD is anatomically accurate with proper flow patterns and motion under pulsatile flow conditions and 4) demonstrating prototype reproducibility, stability and commercial potential during extended evaluations in academic and industrial environments. Design optimization and manufacturing technologies are significantly improved through the introduction of powerful computer based, finite element analysis and CAD/CAM integration with in house CNC prototype hardware. Process technology improvements will assist Phase Ill commercialization. A commercially available eCAD will be critical for the development, validation and training of medical personnel on using state of the art MRA diagnostic protocols for coronary artery disease.