Emergency Brain Monitor with Telemetry

描述(申请人提供)：这是一项第二阶段的延续方案，旨在为大脑提供我们在急诊科几十年来一直在为心脏所做的事情。在我们之前的工作中，我们已经开发并测试了一种紧凑型遥测脑电系统，该系统允许患者在仍被远程PC监控的情况下自由活动。我们在博蒙特医院(密歇根州特洛伊)的急诊科(ED)对20名精神状态改变的患者进行了实时脑电监测。结果表明，该设备在该环境中非常实用和易于使用，并且不会阻碍急诊室的常规护理标准。同样重要的是，结果显示，20名患者中有7名患有非惊厥性癫痫(NCS)；这是一种异常的大脑活动，使用传统程序可能完全忽略了这一点。另外两名患者的相互矛盾的症状也使用我们的技术得到了解决。在这项提案中，我们将完成该技术的开发和商业化，以生产第一个专门用于急诊室的无线脑电设备。我们将使用新的无线发射器升级设备(以满足最近发布的FCC指南)，重新包装审查模块以使其更坚固和可靠，并通过减少脑电电极数量来研究更快的连接时间。密歇根州特洛伊市的博蒙特医院急诊科将进行一项广泛的临床试验。建议的设备在市场上是需要的，我们希望将开创EEG在急诊室和院前环境中广泛使用的先河。一旦记录在PC中，急诊室的实时脑电可以通过局域网和互联网连接传输到医院内外任何地方的神经科医生。该设备还将具有嵌入式癫痫检测算法，以促进神经阅读。最后，虽然我们认识到改变标准方案的潜在阻力，但我们相信，通过将这项技术商业化并即使在少数急救中心成功采用，也将构成一个非常必要的步骤，以说服全国的急救医生和医院管理人员，EEG作为现有急救方案的关键补充的重要性。

DESCRIPTION (provided by applicant): This is a Phase II continuation proposal that is meant to provide for the brain what we have been doing for the heart for decades in the emergency department. During our prior work, we have developed and tested a compact telemetry EEG system that allows the patient to be untethered and moved about freely while still being monitored by a remote PC. We have conducted real time EEG monitoring in the Emergency Department (ED) at Beaumont Hospitals (Troy, Michigan) on twenty patients with altered mental status. The results show that the device is very practical and easy to use in that environment and does not impede conventional standard of care in the ED. As importantly, the results show that 7 of 20 patients had Non-Convulsive Seizures (NCS); abnormal brain activity that could have been totally missed using traditional procedures. Conflicting symptoms in two more patients were also resolved using our technology. In this proposal, we will finalize development and commercialization of the technology to produce the first wireless EEG device that is dedicated to the emergency room. We will upgrade the device with a new wireless transmitter (to meet recently issued FCC guidelines), repackage the review module to make it more rugged and reliable, and investigate faster hookup time by reducing the number of EEG electrodes. An extensive clinical trial will be conducted at Beaumont hospital emergency department in Troy, Michigan. The proposed device is needed in the market place and we hope will pioneer the wide-use of EEG in emergency rooms and in prehospital settings. Once recorded in the PC, real time EEG from the ED can be transferred via LAN and internet connections to a neurologist anywhere inside or outside the hospital. The device will also have an embedded seizure detection algorithm to facilitate neurological reading. Finally, while we recognize the potential resistance to changes in standard protocols, we believe that by commercializing this technology and with successful adoption even by few emergency centers will constitute a much needed step to convince the emergency doctors and hospital administrators nationwide of the importance of EEG as a critical complement to existing ED protocols.