DEVELOPMENT CONSEQUENCES OF INFANT ABUSE IN PRIMATES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究旨在探讨被母亲虐待的猕猴幼仔与未被母亲虐待的猕猴幼仔的行为与神经内分泌发育。在今年的项目中，我们完成了所有受试者的行为和神经内分泌数据。神经内分泌指标包括基线条件下、新奇性试验后以及对地塞米松、CRH激发和ACTH刺激试验的反应时的血浆皮质醇水平。还监测了促肾上腺皮质激素释放激素（CRH）和单胺代谢物的CSF水平。我们已经发表了一些行为数据，记录了受虐待和未受虐待婴儿的早期经历，并表明早期经历对发育具有长期影响，包括成年后虐待行为的发生。我们还发表了初步的激素数据表明，这些早期经验的发展影响与HPA轴的激素的长期变化有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project investigates the behavioral and neuroendocrine development of rhesus macaque infants who are abused by their mothers and their nonabused controls. In this year of the project, we completed our behavioral and neuroendocrine data for all subjects. Neuroendocrine measures included plasma cortisol levels under baseline conditions, following a novelty test, and in response to dexamethasone, CRH challenge, and ACTH stimulation test. CSF levels of corticotropin-releasing-hormone (CRH) and monoamine metabolites were also monitored. We have published some of our behavioral data documenting the early experience of abused and nonabused infants and indicating that early experience has long-lasting consequences for development including the occurrence of abusive behavior in adulthood. We have also published preliminary hormonal data suggesting that some of these developmental effects of early experience are associated with long-term alterations of hormones of the HPA axis.